Evidence map›Paper›PMID 40221528›Full record

ArticleScientific reports2025

Age-related changes in the cytoplasmic ultrastructure of feline oocytes.

Brągiel Natalia, Perrin John, Młodawska Wiesława, Niżański Wojciech, Podhorska-Okołów Marzenna, Haczkiewicz-Leśniak Katarzyna, Kulus Michał, Ochota Małgorzata

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The CHI3L1 protein plays role as a protecting factor against autophagy in glioblastoma cells.Apoptosis : an international journal on programmed cell death · 2026
    Article
  2. Review
  3. Morphological and Functional Evaluation of Kodkod (Animals : an open access journal from MDPI · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brągiel NataliaDepartment of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, Norwida 25, Wroclaw, 50-375, Poland. natalia.anna.bragiel@gmail.com.
Perrin JohnDepartment of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, Norwida 25, Wroclaw, 50-375, Poland.
Młodawska WiesławaDepartment of Animal Reproduction, Anatomy and Genomics, University of Agriculture in Kraków, Kraków, Poland.
Niżański WojciechDepartment of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, Norwida 25, Wroclaw, 50-375, Poland.
Podhorska-Okołów MarzennaDepartment of Ultrastructural Research, Wroclaw Medical University, ul. Chałubińskiego 6a, Wrocław, 50- 368, Poland.
Haczkiewicz-Leśniak KatarzynaDepartment of Ultrastructural Research, Wroclaw Medical University, ul. Chałubińskiego 6a, Wrocław, 50- 368, Poland.
Kulus MichałDepartment of Ultrastructural Research, Wroclaw Medical University, ul. Chałubińskiego 6a, Wrocław, 50- 368, Poland. michal.kulus@umw.edu.pl.
Ochota MałgorzataDepartment of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, Norwida 25, Wroclaw, 50-375, Poland. malgorzata.ochota@upwr.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study elucidates the impact of aging on the cellular architecture of feline oocytes, with a particular emphasis on organelles essential for fertilization and embryo development. Using transmission electron microscopy (TEM), the research compares oocytes from prepubescent, cycling adult, and aged cats, revealing notable differences in the arrangement of key structures, particularly mitochondria, lipid droplets, and vacuoles. Oocytes from adult donors are at their metabolic peak, demonstrating a higher concentration of mitochondria near lipid droplets, supporting efficient energy metabolism. In contrast, younger and older oocytes exhibit larger lipid droplets and reduced mitochondrial density, indicative of diminished metabolic activity. These findings not only underscore the necessity of selecting an optimal donor age for in vitro fertilization but also suggest potential biomarkers for oocyte quality assessment. This novel insight offers promising strategies to enhance reproductive success, improve assisted reproduction outcomes, and support feline conservation efforts.

Indexed as

AgingCytoplasmOocytesAnimalsCatsFemaleLipid DropletsMicroscopy, Electron, TransmissionMitochondriaAgingCatsElectron microscopyFertilityOocytesReproductive biology

Identifiers

PMID40221528
PMCPMC11993646

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.