Evidence map›Paper›PMID 40221525›Full record

ArticleScientific reports2025

Association between methyl donor nutrients' dietary intake with phenotypic aging among US adults: a cross-sectional study from NHANES 2005-2018.

Yong Li, Da Peng, Zhenyuan Yu, Jiaqi Deng, Lijuan Zhao, Ruoyan Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong Li *Department of Stomatology, Hunan University of Medicine, Huaihua, Hunan, China.
Da Peng *Department of Stomatology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Zhenyuan YuDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, 110002, Liaoning, China.
Jiaqi DengDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, 110002, Liaoning, China.
Lijuan ZhaoDepartment of Health Hazards Surveillance, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), No. 568 Mingshi Road, Hangzhou, 310021, Zhejiang, China. zhaolijwy@163.com.
Ruoyan CaoDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, 110002, Liaoning, China. caory1993@163.com.

Funding

National Natural Science Foundation of China 82401133Science and Technology Programme for Disease Prevention and Control of Zhejiang Province 2025JK027
6 · The paper itself

Abstract

This study investigates the association between dietary methyl donor nutrients intake and phenotypic aging. This cross-sectional study comprised 27,211 adult participants from the NHANES 2005-2018. The methyl-donor nutritional quality index (MNQI) was calculated by assessing the intake of the seven methyl donor nutrients: protein, folate, choline, riboflavin, vitamin B6, vitamin B12, and zinc. Phenotypic age acceleration (PhenoAge.Accel) was calculated using biochemical markers to assess biological aging. Weighted generalized linear regression models were utilized to assess the associations between MNQI and PhenoAge.Accel, and the impact of different demographic and health characteristics was evaluated through interaction effect tests. After adjusting for various potential confounding factors, a significant negative association was found between MNQI and PhenoAge.Accel (β = - 0.66; 95% CI - 0.91, - 0.40; P < 0.0001), indicating that an increase in MNQI is associated with a slowdown in PhenoAge.Accel. Furthermore, subgroup analysis indicated stronger negatively association between MNQI and PhenoAge.Accel in males (β = - 0.94; 95% CI - 1.36, - 0.52) with significant interactions (P

Indexed as

AgingDietNutrientsAdultAgedCross-Sectional StudiesFemaleFolic AcidHumansMaleMiddle AgedNutrition SurveysPhenotypeUnited StatesVitamin B 6Folic AcidNutrientsVitamin B 6AdultsMethyl donor nutrientsNHANESPhenotypic age

Identifiers

PMID40221525
PMCPMC11993654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.