Evidence map›Paper›PMID 40221482›Full record

ArticleScientific reports2025

Optogenetic stimulation of inferior colliculus neurons elicits mesencephalic locomotor region activity and reverses haloperidol-induced catalepsy in rats.

José A Pochapski, Jan Franke, Wolfgang Kruse, Ralf Jacob, Stefan Herlitze, Claudio Da Cunha, Rainer K W Schwarting, Liana Melo-Thomas

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

José A PochapskiPharmacology Department, Federal University of Parana, Curitiba, Brazil.
Jan FrankeBehavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.
Wolfgang KruseGeneral Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Ralf JacobDepartment of Cell Biology and Cell Pathology, Philipps-University Marburg, Marburg, Germany.
Stefan HerlitzeGeneral Zoology and Neurobiology, Ruhr-University Bochum, Bochum, Germany.
Claudio Da CunhaPharmacology Department, Federal University of Parana, Curitiba, Brazil.
Rainer K W SchwartingBehavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.
Liana Melo-ThomasBehavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany. melothom@staff.uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inferior colliculus (IC) represents a pivotal midbrain area involved in processing sensory/emotional facets of auditory stimuli, potentially influencing motor responses. Our prior investigations showed that electric or chemical stimulation of the IC ameliorates haloperidol-induced catalepsy, a manifestation of Parkinsonism in animals. We hypothesized that this amelioration stems from a sensory-motor gating mechanism via IC activation of the mesencephalic locomotor region (MLR). Aiming to investigate this hypothesis, we performed IC optogenetic stimulation and electrophysiological recordings of MLR neuronal activity in anesthetized rats. Additionally, we examined whether optogenetic manipulation of IC could improve motor deficits and affect emotional states in awake rats. Electrophysiological data revealed an excitatory response in MLR neurons following IC optogenetic stimulation, with a longer onset latency in MLR neurons suggesting synaptic modulation from IC to MLR. Behavioral results showed that IC optogenetic stimulation improved haloperidol-induced motor deficits without affecting emotional state or basal locomotor activity.

Indexed as

CatalepsyHaloperidolInferior ColliculiLocomotionMesencephalonNeuronsOptogeneticsAnimalsMaleRatsHaloperidolCatalepsyInferior colliculusMesencephalic locomotor regionParadoxical kinesiaParkinson’s disease

Identifiers

PMID40221482
PMCPMC11993560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.