Evidence map›Paper›PMID 40221465›Full record

ArticleScientific reports2025

Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model.

Denise Mayumi Tanaka, Beatriz de Paula Dias Zara, André Timoteo Sapalo, Arthur Lauand Vargas, José Antonio Marin-Neto, Antônio Carlos Leite de Barros-Filho, Cibele M Prado Zinni, Keila Cardoso Barbosa Fonseca, Maykon Tavares de Oliveira, João Santana Silva and 4 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Denise Mayumi TanakaMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Beatriz de Paula Dias ZaraMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
André Timoteo SapaloMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Arthur Lauand VargasMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
José Antonio Marin-NetoMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Antônio Carlos Leite de Barros-FilhoMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Cibele M Prado ZinniMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Keila Cardoso Barbosa FonsecaHeart Institute (Incor), Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Maykon Tavares de OliveiraMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
João Santana SilvaMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Felix Jose Alvarez RamiresHeart Institute (Incor), Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Maria de Lourdes HiguchiHeart Institute (Incor), Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Marcus Vinicius SimõesMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.
Minna Moreira Dias RomanoMedical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil. minna@fmrp.usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurohormonal benefits of Chronic Chagas' Cardiomyopathy (CCC) remain controversial. This study aimed to assess therapeutic interventions on CCC evolution in T. cruzi-infected hamsters at pre and post-treatment (2 months with beta-blocker (CH + BB) or ACE inhibitor (CH + ACEI)). Echocardiography was performed through evolution and compared to histopathological myocardial analysis. At post-treatment, a significant reduction of LV global systolic function and segmental function was observed between the control group and all Chagas' groups. Compared to the Control, a reduction in LV regional strain was observed in three LV segments, regardless of treatment. No differences were observed in apoptosis, myocardial fibrosis, and the number of inflammatory cells among the groups. In an experimental model of CCC, LV global and regional function is compromised, and the treatment with ACEi and BB did not change LV remodeling. Regional LV function was slightly better in animals treated with BB, and this difference was not observed in the CH + ACEi group.

Indexed as

Adrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsChagas CardiomyopathyHeart VentriclesVentricular Function, LeftAnimalsCricetinaeDisease Models, AnimalEchocardiographyMaleTrypanosoma cruziVentricular RemodelingAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAnimal experimental modelChronic Chagas´ cardiomyopathyMyocardial functionNeurohormonal treatmentSpeckle tracking echocardiography

Identifiers

PMID40221465
PMCPMC11993644

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.