Evidence map›Paper›PMID 40221462›Full record

ArticleNPJ Parkinson's disease2025

Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques.

Morgane Darricau, Valentine Kulifaj, Marie-Laure Arotcarena, Qin Li, Taxiarchis Katsinelos, William A McEwan, Maria Xilouri, Benjamin Dehay, Erwan Bezard, Vincent Planche

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Morgane DarricauUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Valentine KulifajUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Marie-Laure ArotcarenaUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Qin LiMotac Beijing services Ltd, Beijing, China.
Taxiarchis KatsinelosDepartment of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
William A McEwanDepartment of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
Maria XilouriCenter of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Benjamin DehayUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Erwan BezardUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
Vincent PlancheUniversité de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France. vincent.planche@u-bordeaux.fr.

Funding

French government in the framework of the University of Bordeaux's IdEx "Investments for the Future" program GPR BRAIN_2030the Innovative Medicines Initiative 2 Joint Undertaking 116060 (IMPRiND)Wellcome TrustWellcome Trust and the Royal Society 206248/Z/17/Z
6 · The paper itself

Abstract

The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.

Identifiers

PMID40221462
PMCPMC11993647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.