ArticleScientific reports2025
Management and survival trends for diffuse gliomas diagnosed at a single neurooncology center in China during 2000 to 2020.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-grade gliomas where resources define survival: a systematic review and meta-analysis of outcomes, surgical access, and molecular diagnostic gaps in low- and middle-income countries.Frontiers in oncology · 2026Pooled it
- FET-PETTranslational cancer research · 2026Article
- Supramaximal resection in gliomas: a narrative review of surgical techniques, clinical outcomes, and ethical considerations.Annals of medicine and surgery (2012) · 2026Review
- Glioblastoma treatment patterns and outcomes over 18 years in an Irish cancer centre.Irish journal of medical science · 2026Article
- Article
- High ALG1 Expression Is Correlated With Poor Prognosis and the Immune Microenvironment in Glioma.Journal of cellular and molecular medicine · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
Currently reported survival outcomes for gliomas exhibit significant variability and controversy. In this study, we aim to provide survival data in Chinese populations by conducting a retrospective analysis of management and survival trends in a large cohort of glioma patients from a single institute in China. A total of 1206 patients with newly diagnosed gliomas treated between 2000 and 2020 were enrolled, including 537 glioblastoma (WHO grade 4), 450 astrocytomas (grade 2/3) and 219 oligodendroglial tumors (grade 2/3). The estimated overall survival at 5 years was 18.9% for glioblastoma, 58.8% for astrocytomas, and 80.7% for oligodendroglial tumors, while median survival was 17.2 months, 82.8 months, and not reached, respectively. The survival trend has increased over the past decades for all types of gliomas. Additionally, similar survival trends were observed between grade 2 and 3 IDH-mutant gliomas. Rising trends were observed in patients undergoing postsurgical radiation and chemotherapy. Multivariate analysis identified adjuvant radiochemotherapy as an independent factor for better prognosis in glioblastoma and astrocytomas. In summary, despite its retrospective nature, this cohort of glioma patients exhibits favorable survival outcomes compared to global statistics, indicating a geographical disparity in glioma prognosis. The promotion of adjuvant chemoradiotherapy contributes to improved prognosis.
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