Evidence map›Paper›PMID 40221424›Full record

ArticleCell death & disease2025

YTHDC1 phase separation drives the nuclear export of m

Shengjun Chen, Yujie Wang, Jinjin Zhang, Bo Liu, Weili Liu, Guohong Cao, Rongrong Li, Hongbo Li, Nailiang Zhai, Xiaodong Song and 2 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  15. RNA 5-Methylcytosine Modification in Myocardial Fibrosis.Reviews in cardiovascular medicine · 2025
    Review
  16. Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shengjun Chen *Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Yujie Wang *Department of Cellular and Genetic Medicine, Binzhou Medical University, Yantai, China.
Jinjin Zhang *Department of Cellular and Genetic Medicine, Binzhou Medical University, Yantai, China.
Bo LiuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Weili LiuDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Guohong CaoDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Rongrong LiDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Hongbo LiDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Nailiang ZhaiDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China.
Xiaodong SongDepartment of Cellular and Genetic Medicine, Binzhou Medical University, Yantai, China. songxd71@163.com.ORCID http://orcid.org/0000-0003-2543-1790
Songzi ZhangDepartment of Cellular and Genetic Medicine, Binzhou Medical University, Yantai, China. szzhang95@gmail.com.ORCID http://orcid.org/0000-0003-2082-0017
Changjun LvDepartment of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, China. lucky_lcj@sina.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81870001National Natural Science Foundation of China (National Science Foundation of China) 81970064National Natural Science Foundation of China (National Science Foundation of China) 82170085National Natural Science Foundation of China (National Science Foundation of China) 82370079National Natural Science Foundation of China (National Science Foundation of China) 82370094National Natural Science Foundation of China (National Science Foundation of China) 82400117
6 · The paper itself

Abstract

Fibroblast-to-myofibroblast differentiation is the main cytopathologic characteristic of pulmonary fibrosis. However, its underlying molecular mechanism remains poorly understood. This study elucidated that the nuclear export of lncNONMMUT062668.2 (lnc668) exacerbated pulmonary fibrosis by activating fibroblast-to-myofibroblast differentiation. Mechanistic research revealed that histone H3K9 lactylation in the promoter region of the N6-methyladenosine (m

Indexed as

AdenosinePulmonary FibrosisRNA-Binding ProteinsRNA, Long NoncodingSerine-Arginine Splicing FactorsActive Transport, Cell NucleusAnimalsCell DifferentiationCell NucleusFibroblastsHumansKaryopherinsMaleMethyltransferasesMiceMice, Inbred C57BLAdenosineKaryopherinsMethyltransferasesNerve Tissue ProteinsN-methyladenosineRNA-Binding ProteinsRNA, Long NoncodingRNA Splicing FactorsSerine-Arginine Splicing FactorsYTHDC1 protein, human

Identifiers

PMID40221424
PMCPMC11993731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.