Evidence map›Paper›PMID 40221394›Full record

ArticleNature communications2025

High-fidelity topochemical polymerization in single crystals, polycrystals, and solution aggregates.

Chongqing Yang, Jianfang Liu, Rebecca Shu Hui Khoo, Maged Abdelsamie, Miao Qi, He Li, Haiyan Mao, Sydney Hemenway, Qiang Xu, Yunfei Wang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Selective conversion of CONature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Chongqing Yang *The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-2538-8545
Jianfang Liu *The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0001-6786-8873
Rebecca Shu Hui KhooThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-0591-5894
Maged AbdelsamieThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Miao QiThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-2232-8739
He LiThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-4076-7279
Haiyan MaoDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720, USA.
Sydney HemenwayThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-6808-8235
Qiang XuChemical Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-3747-4325
Yunfei WangThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Beihang YuThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0001-5060-0766
Qingsong ZhangThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Xinxin LiuKey Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, Chemistry College, Beijing Normal University, Beijing, 100875, P.R. China.
Liana M KlivanskyThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Xiaodan GuSchool of Polymer Science and Engineering Center for Optoelectronic Materials and Devices, The University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID http://orcid.org/0000-0002-1123-3673
Chenhui ZhuAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Jeffrey A ReimerDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-4191-3725
Ganglong CuiKey Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, Chemistry College, Beijing Normal University, Beijing, 100875, P.R. China.ORCID http://orcid.org/0000-0002-9752-1659
Carolin M Sutter-FellaThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-7769-0869
Jian ZhangThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-0274-0814
Gang RenThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-8036-2321
Yi LiuThe Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. yliu@lbl.gov.ORCID http://orcid.org/0000-0002-3954-6102

Funding

STRUCTURAL ANALYSIS OF THE MANNOSE 6-PHOSPHATE RECEPTORSR01DK042667 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI DAHMS, NANCY M. · 1997 to 2023
$9.8M
Synaptic Organizers: Dynamic Regulation of Trans-synaptic BridgesR01MH077303 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Gabrielle Rudenko · 2006 to 2026
$8.2M
Structure-Function Relationship Studies of the Plasma Lipid Transfer Proteins CETP and PLTPR01HL115153 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI REN, GANG · 2012 to 2021
$3.9M
Lipoprotein Structure and Function by Individual Particle Electron TomographyR01GM104427 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI REN, GANG · 2013 to 2016
$1.3M
DOE | SC | Basic Energy Sciences (BES) DE-AC02-05CH11231NHLBI NIH HHS R01 HL115153NIDDK NIH HHS R01 DK042667NIGMS NIH HHS R01 GM104427NIMH NIH HHS R01 MH077303
6 · The paper itself

Abstract

Topochemical polymerization (TCP) emerges as a leading approach for synthesizing single crystalline polymers, but is traditionally restricted to transformations in solid-medium. The complexity in achieving single-crystal-to-single-crystal (SCSC) transformations due to lattice disparities and the untapped potential of performing TCP in a liquid medium with solid-state structural fidelity present unsolved challenges. Herein, by using X-rays as the primary means to overcome crystal disintegration, we reveal the details of SCSC transformation during the TCP of chiral azaquinodimethane (AQM) monomers through in situ crystallographic analysis while spotlighting a rare metastable crystalline phase. Complementary in situ investigations of powders and thin films provide critical insights into the side-chain dependent polymerization kinetics of solid-state reactions. Furthermore, we enable TCP of AQM monomers in a liquid medium via an antisolvent-reinforced aggregated state, yielding polymer nanofibers with high crystallinity akin to that of solid-state. This study testifies high structural precision of TCP performed in different states and media, offering critical insights into the synthesis of processable nanostructured polymers with desired structural integrity.

Identifiers

PMID40221394
PMCPMC11993752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.