ArticleBritish journal of anaesthesia2025
Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies.
Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review).International journal of molecular medicine · 2026Review
- From index to insight: clinical perspectives on electroencephalographic spectrogram-guided anesthesia-a narrative review.Korean journal of anesthesiology · 2026Review
- Effects of spontaneous breathing anesthesia on postoperative cognitive dysfunction in elderly patients: a narrative review.Frontiers in surgery · 2026Review
- Perioperative dynamic EEG patterns correlated with changes in cognitive subdomains.Clinical neurophysiology practice · 2026Article
- Development of a deep learning-based prediction model for postoperative delirium using intraoperative electroencephalogram in adults.NPJ digital medicine · 2025Article
- Age-specific electroencephalography dynamics during anesthesia: monitoring and neurocognitive implications.Anesthesia and pain medicine · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundWe previously have shown that low intraoperative EEG alpha power is associated with impaired preoperative cognition, a delirium risk factor, and that intraoperative anaesthetic-dose-adjusted EEG bispectral index values were associated with a four-fold increased risk of postoperative delirium (POD). Yet, associations between intraoperative anaesthetic-dose-adjusted alpha power and delirium or delirium risk factors have yet to be quantified.
methodsWe examined cerebrospinal fluid (CSF) Alzheimer's disease (AD)-related biomarkers, cognitive scores, EEG recordings, and delirium data from 82 noncardiac, non-neurologic surgical patients ≥60 yr in age. Based on prior work, each participant's intraoperative frontoparietal EEG alpha power was anaesthetic dose-adjusted by dividing it by (2.5 minus the age-adjusted end-tidal minimum alveolar concentration), and then analysed for its association with POD and delirium risk factors, preoperative CSF AD-related biomarkers, and preoperative cognition.
resultsLower anaesthetic-dose-adjusted frontoparietal alpha power was associated with increased odds of POD (odds ratio [95% confidence interval (CI)]: 1.44 [1.09, 1.89], P=0.009) and moderate-to-severe delirium (odds ratio [95% CI]: 1.44 [1.04, 2.00], P=0.030). Anaesthetic-dose-adjusted frontoparietal alpha power was not associated with pathologic concentrations of CSF pTau-181, Aβ1-42, or pTau-181/Aβ1-42 (P>0.05). In multivariable cognitive models, anaesthetic-dose-adjusted frontoparietal alpha power was associated with preoperative timed processing speed/executive function performance (β [95% CI]: 0.27 [0.06, 0.49], P=0.014), but not with untimed attention/memory performance (β [95% CI]: 0.12 [-0.13, 0.37], P=0.349).
conclusionsLower intraoperative anaesthetic-dose-adjusted frontoparietal alpha power was associated with delirium and delirium-predisposing factors (impaired preoperative processing speed/executive function in timed attention tasks). Larger studies are warranted to confirm these associations after further adjustment for covariates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.