Evidence map›Paper›PMID 40221237›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Baseline habitual dietary nitrate intake and Alzheimer's Disease related neuroimaging biomarkers in the Australian Imaging, Biomarkers and Lifestyle study of ageing.

Anjana Rajendra, Nicola P Bondonno, Kevin Murray, Liezhou Zhong, Stephanie R Rainey-Smith, Samantha L Gardener, Lauren C Blekkenhorst, Vincent Doré, Victor L Villemagne, Simon M Laws and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Can Beetroot (Nutrients · 2025
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anjana RajendraNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Nicola P BondonnoNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia; The Danish Cancer Institute, Copenhagen, Denmark.
Kevin MurraySchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
Liezhou ZhongNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Stephanie R Rainey-SmithCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Lifestyle Approaches Towards Cognitive Health Research Group, Murdoch University, Murdoch, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Australian Alzheimer's Research Foundation, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Perth, Western Australia, Australia.
Samantha L GardenerLifestyle Approaches Towards Cognitive Health Research Group, Murdoch University, Murdoch, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Australian Alzheimer's Research Foundation, Nedlands, Western Australia, Australia.
Lauren C BlekkenhorstNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia; For a full list of the AIBL Research Group see aibl.org.au.
Vincent DoréAustralian E-Health Research Centre, CSIRO, 351 Royal Parade, Parkville, Victoria, Australia; Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, Australia.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, Australia; Department of Psychiatry, University of Pittsburgh, Thomas Detre Hall, 3811 O'Hara Street, Pittsburgh, PA, USA; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, Australia.
Simon M LawsCentre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, Australia; Collaborative Genomics and Translation Group, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Kent Street, Bentley, Western Australia, Australia.
Belinda M BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Lifestyle Approaches Towards Cognitive Health Research Group, Murdoch University, Murdoch, Western Australia, Australia; Collaborative Genomics and Translation Group, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia, Australia.
Kevin TaddeiCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Colin L MastersThe Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, Australia; The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Jonathan M HodgsonNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia; Medical School, The University of Western Australia, Royal Perth Hospital Research Foundation, Perth, Western Australia, Australia.
Catherine P BondonnoNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia; Medical School, The University of Western Australia, Royal Perth Hospital Research Foundation, Perth, Western Australia, Australia. Electronic address: c.bondonno@ecu.edu.au.
AIBL Research GroupFor a full list of the AIBL Research Group see aibl.org.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary nitrate, as a nitric oxide (NO) precursor, may support brain health and protect against dementia.

objectiveOur primary aim was to investigate whether dietary nitrate is associated with neuroimaging markers of brain health linked with Alzheimer's disease (AD).

participantsStudy participants were cognitively unimpaired individuals from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) who had β-amyloid positron emission tomography (PET) scans (n = 554) and magnetic resonance imaging (MRI) scans (n = 335) and had completed a Food Frequency Questionnaire at baseline.

methodsSource-specific nitrate intakes were estimated using comprehensive nitrate food composition databases. Rates of cerebral β-amyloid (Aβ) deposition, measured using PET, and rates of brain atrophy, measured using MRI, were assessed between baseline and 126-months follow-up, at intervals of 18 months. Multivariable-adjusted linear mixed effect models were used to examine associations between baseline source-specific nitrate intake and rates of (i) cerebral Aβ deposition and (ii) brain atrophy, over the 126 months of follow-up. Analyses were carried out following stratification of the sample by established dementia Alzheimer's disease (AD) risk factors including sex and presence or absence of the apolipoprotein E (APOE) ε4 allele.

resultsIn women carriers of the APOE ε4 allele, higher plant sourced nitrate intake (median intake 121 mg/day), was associated with a slower rate of cerebral Aβ deposition [β: 4.47 versus 8.99 Centiloid (CL) /18 months, p < 0.05] and right hippocampal atrophy [-0.01 versus -0.03 mm3 /18 months, p < 0.01], after multivariable adjustments. Moderate intake showed protective associations in men carriers and in both men and women non-carriers of APOE ε4.

conclusionsAssociations were observed between plant-derived nitrate intake and cerebral Aβ deposition, particularly in high-risk populations (women and APOE ε4 carriers). Associations were also observed for brain volume atrophy, however these exhibited subgroup variability without clear patterns relative to sex and APOE ε4 allele carriage. These findings suggest a potential link between plant-sourced nitrate and AD related neuroimaging markers of brain health improved brain health, but further validation in larger studies is required.

Indexed as

AgingAlzheimer DiseaseBrainDietNitratesAgedAged, 80 and overAmyloid beta-PeptidesAtrophyAustraliaBiomarkersFemaleHumansLife StyleMagnetic Resonance ImagingMaleAmyloid beta-PeptidesBiomarkersNitratesAlzheimer's diseaseApoeBrain atrophyCerebral beta-amyloidDementiaDietNeuroimaging brain biomarkersNitrate

Identifiers

PMID40221237
PMCPMC12434242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.