ArticleGynecologic oncology2025
An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor.
Article in Gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Expression of antibody drug conjugate target antigens in ovarian sex cord stromal Tumors.Gynecologic oncology · 2026Article
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10 authors.
Funding
Abstract
backgroundAdult-type granulosa cell tumors (AGCTs) are rare ovarian sex cord/stromal tumors with near-universal hotspot mutations in FOXL2 (c.C402G; p.Cys134Trp). Progress in the treatment of relapsed AGCT has been hindered by the lack of high-fidelity FOXL2-based mouse models. To address this critical unmet need, we created and validated a genetically engineered inducible mouse model of the human FOXL2 mutation that recapitulates the key features of the human disease.
methodsGene targeting in embryonic stem cells was used to introduce a Cre-inducible Foxl2
resultsFemale Amhr2-Cre; Foxl2
conclusionsA Amhr2-Cre; Foxl2
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