ArticleJournal of neuroscience methods2025
Precisely-timed outpatient recordings of subcortical local field potentials from wireless streaming-capable deep-brain stimulators: a method and toolbox.
Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- DBSsync: combining intracranial and multimodal data to investigate new biomarkers in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundInvestigations of the electrophysiological mechanisms of the human subcortex have relied on recording local field potentials (LFPs) during deep-brain stimulation (DBS) neurosurgery. However, the neurosurgical setting severely restricts the research use of these recordings. Recently developed sensing-capable DBS devices wirelessly stream subcortical LFPs in outpatient settings. These recordings have tremendous potential for research. However, synchronizing them with other behavior or neural recordings is challenging, as the clinical devices do not accept digital timing information. NEW
methodSwitching the DBS device on introduces transient yet consistent artifacts in both the LFP and simultaneous scalp-EEG recordings. We use these artifacts as a reference to align these recordings (N = 20). We tested whether the alignment was precise enough to match a ground truth state (large artifacts produced by transcranial magnetic stimulation, TMS), yielded trial-averaged event-locked LFPs, and phase consistency across trials. We further evaluated the consistency of task-related LFPs across outpatient and perisurgical recordings. RESULTS AND COMPARISON WITH EXISTING METHOD(S): Previous alignment methods were limited because they relied on inconsistent on/offset features of DBS artifacts caused by ongoing stimulation. Moreover, they only provided limited validation. Our highly precise alignment method showed a maximum deviation of only 8 ms - clearly superior to prior techniques. Furthermore, event-related activity patterns were comparable across outpatient and perisurgical LFP recordings.
conclusionsWe present a method and a MATLAB toolbox that inserts the most precise digital timing information into wirelessly-streamed DBS-LFP recordings to date. By enabling event-related research with high-temporal precision, this method greatly enhances the utility of these recordings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.