Evidence map›Paper›PMID 40220753›Full record

ArticleStructure (London, England : 1993)2025

Structural insights into the assembly and regulation of 2'-O RNA methylation by SARS-CoV-2 nsp16/nsp10.

Anurag Misra, R Rahisuddin, Manish Parihar, Shailee Arya, Thiruselvam Viswanathan, Nathaniel Jackson, Shan Qi, Siu-Hong Chan, Reuben S Harris, Luis Martinez-Sobrido and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Anurag MisraGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
R RahisuddinGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Manish PariharGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Shailee AryaGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Thiruselvam ViswanathanGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Nathaniel JacksonTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Shan QiGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Siu-Hong ChanNew England Biolabs, 240 County Road, Ipswich, MA 01938, USA.
Reuben S HarrisDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA; Howard Hughes Medical Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Luis Martinez-SobridoTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Yogesh K GuptaGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA. Electronic address: guptay@uthscsa.edu.

Funding

Project 5: Pandemic Virus Helicase InhibitorsU19AI171954 · NIAID · UNIVERSITY OF MINNESOTA · PI Donghoon Chung · 2022 to 2026
$100.9M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Mechanism-based Targeting of the RNA Processing Machinery of SARS-CoV-2R01AI161363 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUPTA, YOGESH K · 2021 to 2025
$3.2M
NIAID NIH HHS R01 AI161363NIAID NIH HHS U19 AI171954NIGMS NIH HHS P30 GM124165
6 · The paper itself

Abstract

2'-O-ribose methylation of the first transcribed base (adenine or A

Indexed as

ExoribonucleasesRNA, ViralSARS-CoV-2Viral Nonstructural ProteinsViral Regulatory and Accessory ProteinsBinding SitesCatalytic DomainCrystallography, X-RayHumansMethylationMethyltransferasesModels, MolecularProtein BindingProtein MultimerizationRNA CapsRNA MethylationExoribonucleasesMethyltransferasesNSP16 protein, SARS-CoV-2ORF1ab polyprotein, SARS-CoV-2RNA CapsRNA, ViralViral Nonstructural ProteinsViral Regulatory and Accessory ProteinsNsp10Nsp16RNA cappingRNA methylation

Identifiers

PMID40220753
PMCPMC12145257

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.