Evidence map›Paper›PMID 40220509›Full record

Trial reportThe International journal on drug policy2025

The effectiveness of the communities that HEAL intervention on reducing non-fatal opioid overdoses: A prespecified secondary analysis of a waitlist cluster control randomized controlled trial.

Louisa Gilbert, Rouba Chahine, Redonna Chandler, Daniel J Feaster, Erin Kim, Arnie Aldridge, Sarah Bagley, Peter Balvanz, Soledad Fernandez, Peter Rock and 41 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The International journal on drug policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04111939 (HEALing Communities Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04111939 nacompletednot on this map

HEALing Communities Study: Developing and Testing an Integrated Approach to Address the Opioid Crisis

TypeinterventionalSponsorRTI InternationalRan2019 to 2025Enrolled67ConditionsOpioid Use Disorder (OUD)ArmsCommunities That HEAL, Wait-list control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Louisa GilbertSchool of Social Work, Columbia University, New York, NY, USA. Electronic address: lg123@columbia.edu.
Rouba ChahineResearch Triangle Institute International, Research Triangle Park, NC, USA.
Redonna ChandlerNational Institute on Drug Abuse, Gaithersburg, MD, USA.
Daniel J FeasterMiller School of Medicine, University of Miami, Miami, FL, USA.
Erin KimSchool of Social Work, Columbia University, New York, NY, USA.
Arnie AldridgeResearch Triangle Institute International, Research Triangle Park, NC, USA.
Sarah BagleyChobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.
Peter BalvanzBoston Medical Center, Boston, MA, USA.
Soledad FernandezCollege of Public Health, Ohio State University, Columbus, OH, USA.
Peter RockCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Rachel A Vickers-SmithCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Jennifer VillaniNational Institute on Drug Abuse, Gaithersburg, MD, USA.
Tracy BattagliaChobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.
Jennifer BrownDepartment of Psychological Sciences, Purdue University, Lafayette, IN, USA.
Heather BushCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Rachel P ChaseCollege of Medicine, Ohio State University, Columbus, OH, USA.
Thomas CollinsMetroHealth System, Cleveland, OH, USA.
Lauren D'CostaResearch Triangle Institute International, Research Triangle Park, NC, USA.
Carolyn Damato-MacPhersonBoston Medical Center, Boston, MA, USA.
James L DavidSchool of Social Work, Columbia University, New York, NY, USA.
Jolene Defiore-HyrmerState of Ohio Board of Pharmacy, Columbus, OH, USA.
Patricia R FreemanCollege of Pharmacy, University of Kentucky, Lexington, KY, USA.
LaShawn GlasgowResearch Triangle Institute International, Research Triangle Park, NC, USA.
Lindsey R HammerslagCollege of Medicine, University of Kentucky, Lexington, KY, USA.
Juanita HotchkissSchool of Social Work, Columbia University, New York, NY, USA.
Timothy HuntSchool of Social Work, Columbia University, New York, NY, USA.
Shazia HussainOffice of Addiction Services and Supports, New York State, Albany, NY, USA.
Vivian KamanuOffice of Science, New York State Department of Health, Albany, NY, USA.
Charlie KnottResearch Triangle Institute International, Research Triangle Park, NC, USA.
Hannah K KnudsenCollege of Medicine, University of Kentucky, Lexington, KY, USA.
Marc LaRochelleChobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.
Andrew LaudateBoston Medical Center, Boston, MA, USA.
Michael LyonsWexner Medical Center, Ohio State University, Columbus, OH, USA.
Jason McMullanCollege of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Julie NakayimaDepartment of Behavioral Science and Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
Bruce R SchackmanWeill Cornell Medicine, New York, NY, USA.
Svetla SlavovaCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Sylvia TanResearch Triangle Institute International, Research Triangle Park, NC, USA.
Nathan VandergriftResearch Triangle Institute International, Research Triangle Park, NC, USA.
Scott T WaltersHealth Science Center at Fort Worth, The University of North Texas, Fort Worth, TX, USA.
Philip M WestgateCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Elwin WuSchool of Social Work, Columbia University, New York, NY, USA.
April M YoungCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Gary A ZarkinResearch Triangle Institute International, Research Triangle Park, NC, USA.
Bridget FreisthlerCollege of Social Work, Ohio State University, Columbus, OH, USA.
Emmanuel OgaResearch Triangle Institute International, Research Triangle Park, NC, USA.
Jeffrey H SametChobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.
Sharon L WalshDepartment of Behavioral Science and Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY, USA.
John WinhusenCollege of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Rebecca JacksonCollege of Medicine, Ohio State University, Columbus, OH, USA.
Nabila El-BasselSchool of Social Work, Columbia University, New York, NY, USA.

Funding

Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)UM1DA049406 · NIDA · UNIVERSITY OF KENTUCKY · PI WALSH, SHARON L. · 2019 to 2022
$81.7M
CHASE: An Innovative County-Level Public Health Response to the Opioid Epidemic in New York StateUM1DA049415 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2019 to 2023
$77.3M
Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
NIDA NIH HHS T32 DA037801NIDA NIH HHS UM1 DA049406NIDA NIH HHS UM1 DA049415
6 · The paper itself

Abstract

introductionAlong with a surge of opioid overdose deaths in the United States, the rates of nonfatal opioid overdose (NFOO) emergency department (ED) visits and hospitalizations have been sharply increasing.

methodsIn the HEALing Communities Study (HCS), we conducted a pre-specified secondary analyses to evaluate the effectiveness of the Community that HEALS (CTH) intervention on reducing the count of NFOO ED visits and hospitalizations in a multi-site cluster randomized multi-site, two-arm, parallel, community-level, open, wait list-controlled trial study, Sixty-seven communities in Kentucky, Massachusetts, New York, and Ohio were randomized to the intervention (N = 34) or waitlist control condition (N = 33) stratified by state and balanced by urban/rural classification, fatal opioid overdose rate and population size of communities. We compared the rate of NFOO per 100,000 adults aged ≥18 years between intervention and control communities from July 1, 2021, to June 30, 2022. Rates were calculated in per 100,000 or per 100 adult population measured by inpatient and ED records for intervention community residents with an ICD-10-CM code for opioid poisoning.

resultsCompared to control communities, intervention communities had 15 % fewer NFOO per capita (aRR = 0.85; 95 % CI = [0.74,0.96]; p-value=0.013). Effect modifications by state, urban/rural status, sex, age, race and ethnicity were not significant. DISCUSSION: These findings suggest the intervention reduced NFOO ED visits and hospitalizations. The lack of effect modifications suggests that the intervention may be effective in a wide range of communities in the U.S. Further research is needed to identify the mechanisms through which the intervention reduces NFOO.

trial registrationClinicalTrials.gov Identifier: NCT04111939.

Indexed as

Drug OverdoseEmergency Service, HospitalOpiate OverdoseAdolescentAdultFemaleHospitalizationHumansMaleMiddle AgedUnited StatesWaiting ListsYoung AdultCommunity coalitionsMedications for opioid use disorderNaloxoneNon-fatal opioid overdoseOpioid epidemic

Identifiers

PMID40220509
PMCPMC12103987

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.