ArticleCell reports2025
Disuse-driven plasticity in the human thalamus and putamen.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Brain organization of a memory champion.bioRxiv : the preprint server for biology · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Measuring neuroplasticity in human development: the potential to inform the type and timing of mental health interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Extraction of robust functional connectivity patterns across psychiatric disorders using principal component analysis-based feature selection.Imaging neuroscience (Cambridge, Mass.)Article
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24 authors.
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Abstract
Subcortical plasticity has mainly been studied using invasive electrophysiology in animals. Here, we leverage precision functional mapping (PFM) to study motor plasticity in the human subcortex during 2 weeks of upper-extremity immobilization with daily resting-state and motor task fMRI. We found previously that, in the cortex, limb disuse drastically impacts disused primary motor cortex functional connectivity (FC) and is associated with spontaneous fMRI pulses. It remains unknown whether disuse-driven plasticity pulses and FC changes are cortex specific or whether they could also affect movement-critical nodes in the thalamus and striatum. Tailored analysis methods now show spontaneous disuse pulses and FC changes in the dorsal posterior putamen and central thalamus (centromedian [CM], ventral-intermediate [VIM], and ventroposterior-lateral nuclei), representing a motor circuit-wide plasticity phenomenon. The posterior putamen effects suggest plasticity in stimulus-driven habit circuitry. Importantly, thalamic plasticity effects are focal to nuclei used as deep brain stimulation targets for essential tremor/Parkinson's disease (VIM) and epilepsy/coma (CM).
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