ArticleMolecular neurobiology2025
DjCapon Affects the Neural Regeneration and Light Sensitivity via NO and Wnt5a Signaling in Planarian Dugesia japonica.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The carboxy-terminal postsynaptic density protein 95/discs large protein/zonula occludens 1 (PDZ) ligand of neuronal nitric oxide synthase (nNOS), known as CAPON, can interact with nNOS to influence neuropathological processes. However, the precise mechanism by which CAPON regulates neuronal regeneration remains poorly understood. In this study, we utilized the planarian Dugesia japonica, a model organism renowned for its remarkable regenerative abilities, to investigate this mechanism. First, we cloned the DjCapon gene and performed RNA interference (RNAi) to knock down DjCapon expression in planarians. Our results revealed that DjCapon knockdown impaired neural regeneration, particularly affecting the regeneration of GABAergic neurons. This impairment led to a reduced sensitivity to light in planarians. Furthermore, DjCapon knockdown decreased the activity of nitric oxide synthase (NOS) and reduced the levels of nitric oxide (NO) in planarians. During neural regeneration, the expression of genes associated with the Wnt/Ca
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