Evidence map›Paper›PMID 40220187›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Hearing loss in Chinese osteogenesis imperfecta patients.

Yuan Tian, Yanxuan Shao, Yazhao Mei, Yunyi Jiang, Zhenlin Zhang, Hao Zhang

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yuan TianDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanxuan ShaoDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yazhao MeiDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunyi JiangDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenlin ZhangDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangzl@sjtu.edu.cn.
Hao ZhangDepartment of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhanghaozcl@163.com.ORCID http://orcid.org/0000-0002-8909-049X

Funding

National Key Research and Development Program of China 2021YFC2501701National Natural Science Foundation of China 81870618National Natural Science Foundation of China 82070903National Natural Science Foundation of China 82200988National Natural Science Foundation of China 82270932
6 · The paper itself

Abstract

proposeOsteogenesis imperfecta (OI) is a genetic connective tissue disorder primarily characterized by bone fragility. Hearing loss is an extra-skeletal manifestation of OI. This study aims to characterize the audiological findings of a sample of patients with OI in China.

methodsA total of 76 patients (aged 4-77 years) were recruited and evaluated using audiometric evaluations, including pure tone audiometry (PTA), acoustic admittance measurements, and distortion-product otoacoustic emissions (DPOAEs). Patients were categorized into 2 age groups: adults (more than 18 years) and children (under 18 years), and classified by hearing type: normal hearing, conductive, sensorineural, or mixed hearing loss.

resultsTympanometry (152 ears) showed 71.7% Type A tympanograms. There was a significant association between tympanogram type and hearing loss (p < 0.01). DPOAEs were predominantly abnormal in ears with sensorineural and mixed hearing loss (p < 0.01). PTA (146 ears) revealed hearing loss in 39.0%: 16.4% conductive, 15.1% sensorineural, and 7.5% mixed. Age correlated significantly with hearing loss type (p < 0.01). Adults' group exhibited higher pure-tone averages (11.3 dB vs. 8.8 dB, p < 0.01), average air-bone gap (2.5 dB vs.2.5 dB, p < 0.05), and bone conduction thresholds than children's group.

conclusionsHearing loss is common and progressive in Chinese OI patients, with a significant age-related increase in both the prevalence and severity of hearing loss. Establishing a hearing baseline and regular follow-up is essential for early intervention.

Indexed as

Hearing LossHearing Loss, SensorineuralOsteogenesis ImperfectaAcoustic Impedance TestsAdolescentAdultAgedAudiometry, Pure-ToneChildChild, PreschoolChinaEast Asian PeopleFemaleHearing Loss, ConductiveHumansMaleAudiometric evaluationsHearing lossOsteogenesis imperfectaPure tone audiometry

Identifiers

PMID40220187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.