Evidence map›Paper›PMID 40220180›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Comparison of gadolinium-enhanced MRI of the inner ear with definite Meniere's disease in the detection of endolymphatic hydrops between intratympanic and intravenous injection.

Jianjian Huang, Cheng Tang, Wuming Li, Yiwei Feng, Songhua Tan, Hongxia Zuo, Ping Xiao, Wei Ye, Zeyi Deng, Anzhou Tang

Abstract readComparative Study
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Jianjian Huang *Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.ORCID http://orcid.org/0000-0002-8375-8719
Cheng Tang *Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wuming Li *Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yiwei FengDepartment of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Songhua TanDepartment of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hongxia ZuoCenter for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Ping XiaoDepartment of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Wei YeDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zeyi DengDepartment of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. jordandzy@hotmail.com.
Anzhou TangDepartment of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. anzhoutang@foxmail.com.

Funding

Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project S2022067Medical Science and Technology Foundation of Guangdong Province B2024221
6 · The paper itself

Abstract

objectiveWe aimed to compare the success rate of the inner-ear visualization and actual endolymphatic hydrops (EH) detection rate of gadolinium-enhanced MRI in ears with definite Meniere's disease (dMD) with intratympanic versus intravenous injection.

methods122 ears with dMD were included and divided into the intratympanic (IT) administration and intravenous (IV) groups. 38 ears in the IT group were evaluated by 3D-real IR and 3D-FLAIR sequence scans 24 h after injection of 8-fold diluted gadolinium. 84 ears in IV group were evaluated by i3D-real IR sequence scans 4 h after intravenous gadolinium administration. The success rate and the detection rate of EH were evaluated and analysed.

resultsThe i3D-real IR sequence in the IV group had a higher success rate (100%) than did the 3D-real IR (76.32%) and 3D-FLAIR (84.21%) sequences in the IT group. The actual EH detection rate in the IV group (98.81%) was significantly higher than that for the 3D-real IR (76.32%), 3D-FLAIR (78.95%) or 3D-real IR + 3D-FLAIR (84.21%) sequences in the IT group. The presence of EH could not accurately be assessed in 15.79% of ears in the IT group due to weak perilymph enhancement. After exclusion of these ears, the IT and IV groups showed similar EH detection rates.

conclusionThe insufficient success rate of IT method reduced its actual EH detection rate. Using i3D-real IR, the IV method offers the higher success and actual EH detection rates, which provides a reference to the individualized choice of gadolinium-enhanced MRI.

Indexed as

Contrast MediaEar, InnerEndolymphatic HydropsGadoliniumMagnetic Resonance ImagingMeniere DiseaseAdultAgedFemaleGadolinium DTPAHumansImaging, Three-DimensionalInjection, IntratympanicInjections, IntravenousMaleMiddle AgedContrast MediaGadoliniumGadolinium DTPAEndolymphatic hydropsGadolinium-enhanced MRIIntratympanic injectionIntravenous injectionMénière's disease

Identifiers

PMID40220180

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.