Evidence map›Paper›PMID 40220122›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Prediction of lymph node metastasis in stage I-III colon cancer patients younger than 40 years.

Wei-Hao Zhang, Meng-Di Huang, Yan-Ling Tu, Kun-Zhai Huang, Chao-Jun Wang, Zhao-Hui Liu, Rui-Sheng Ke

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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Wei-Hao ZhangDepartment of General Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China.
Meng-Di HuangXinglin Street Community Health Service Center, Jimei District, Xiamen, 361003, Fujian, China.
Yan-Ling TuDepartment of Neurology, The Zhongshan Hospital Affiliated to Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, Fujian, China.
Kun-Zhai HuangDepartment of General Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China.
Chao-Jun WangDepartment of General Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China. 26900713@qq.com.
Zhao-Hui LiuDepartment of General Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China. 13959277591@163.com.
Rui-Sheng KeDepartment of General Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55, Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China. ringsonke@163.com.ORCID http://orcid.org/0000-0001-9269-4692

Funding

Natural Science Research Project of Guizhou Province 2021J011352The Natural Science Foundation of Xiamen,China 3502Z2022D1002The Natural Science Foundation of Xiamen,China 3502Z202372081The Natural Science Foundation of Xiamen,China 3502Z20244ZD1022
6 · The paper itself

Abstract

aimsDeveloping a clinical model to predict the individual risk of lymph node metastasis (LNM) in young colon cancer (CC) patients may address an unmet clinical need.

methodsA total of 2,360 CC patients under 40 years old were extracted from the SEER database and randomly divided into development and validation cohorts. Risk factors for LNM were identified by using a logistic regression model. A weighted scoring system was built according to beta coefficients (β) calculated by a logistic regression model. Model discrimination was evaluated by C-statistics, model calibration was evaluated by H-L test and calibration plot.

resultsRisk factors were identified as T stage, tumor site, grade and histology. The area under the receiver operating characteristic curve (AUC-ROC) was 0.66 in both cohorts, indicating acceptable discriminatory power. The H-L test showed good calibration in the development cohort (χ

conclusionThis clinical risk prediction model is accurate enough to identify young CC patients with high risk of LNM and can further provide individualized clinical reference.

Indexed as

Colonic NeoplasmsAdultFemaleHumansLogistic ModelsLymphatic MetastasisMaleNeoplasm StagingRisk AssessmentRisk FactorsROC CurveSEER ProgramYoung AdultColon cancerLymph node metastasisPrediction modelYoung patient

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.