Evidence map›Paper›PMID 40220034›Full record

ArticleHuman cell2025

Ovarian Leydig cells and neural crests.

José-Luis Carrasco-Juan, Olga Tapia, Miriam González-Gómez, Abian Vega-Falcón, Sonia García-Hernández, Alexis Rufino-Gómez, Rafael Méndez-Medina, Hugo Álvarez-Arguelles Cabrera

Abstract read
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In one paragraph

Article in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José-Luis Carrasco-JuanÁrea de Histología, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain. jcarraju@ull.edu.es.ORCID http://orcid.org/0000-0001-9140-2053
Olga TapiaÁrea de Histología, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Miriam González-GómezÁrea de Anatomía, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Abian Vega-FalcónÁrea de Anatomía Patológica, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Sonia García-HernándezÁrea de Histología, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Alexis Rufino-GómezInstituto de Tecnologías Biomédicas, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Rafael Méndez-MedinaÁrea de Anatomía Patológica, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.
Hugo Álvarez-Arguelles CabreraÁrea de Anatomía Patológica, Departamento de Ciencias Médicas Básicas, Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, C/Santa María Soledad s/n, Apartado 456, 38200, Santa Cruz de Tenerife, Islas Canarias, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our search for markers to identify and study ovarian Leydig cells, we utilized immunohistochemical techniques and visualized the results using conventional and confocal microscopy. We successfully employed steroidogenic factor- 1 (SF1), androgen receptor (AR), and class III β-tubulin as markers. SF1 and AR specifically highlighted the intraneural cell precursors of Leydig cells, which were previously identified in a published case of mature cystic teratoma of the ovary, and the adult ovarian Leydig cells. Furthermore, the transient expression of class III β-tubulin could be associated with the intraneural displacement of these precursors, cooperating in their migration to colonize the ovaries of adult women.

Indexed as

Leydig CellsNeural CrestOvaryAdultBiomarkersFemaleHumansImmunohistochemistryOvarian NeoplasmsReceptors, AndrogenSteroidogenic Factor 1TeratomaTubulinBiomarkersNR5A1 protein, humanReceptors, AndrogenSteroidogenic Factor 1TubulinAndrogen receptorClass III β-tubulinMature cystic teratomaNeural crestsOvarian Leydig cellsSteroidogenic factor- 1

Identifiers

PMID40220034
PMCPMC11993499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.