Evidence map›Paper›PMID 40220025›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

MST1/2 DKO abates salvianolic acid B's therapeutic effect on CCl

Yanyan Xu, Yu Zhang, Mengru Yang, Changfeng Xue, Yuqi Dang, Yan Yang, YongfangGong

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanyan XuDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China.
Yu ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China.
Mengru YangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China.
Changfeng XueDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China.
Yuqi DangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China.
Yan YangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China. yangyan@ahmu.edu.cn.
YongfangGongDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Hefei, 230032, China. gongyongfang@ahmu.edu.cn.

Funding

Anhui Medical University Research Fund 2021xkj285National Natural Science Foundation of China 82374084National Natural Science Foundation of China 82404966Research Fund of Anhui Institute of translational medicine 2023zhyx-C16the University Natural Science Research Project of Anhui Province 2022AH050714
6 · The paper itself

Abstract

MST1 and MST2 (MST1/2) are core kinases of the Hippo/YAP signaling pathway in mammals and play key roles in various liver diseases. Deep molecular profiling has shown that the Hippo/YAP pathway interacts synergistically with TGF-β

Indexed as

BenzofuransChemical and Drug Induced Liver InjuryProtein Serine-Threonine KinasesSerine-Threonine Kinase 3AnimalsCarbon TetrachlorideDepsidesHippo KinasesLiverMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSmad2 ProteinBenzofuransCarbon TetrachlorideDepsidesHippo KinasesProtein Serine-Threonine Kinasessalvianolic acid BSerine-Threonine Kinase 3Smad2 ProteinSmad2 protein, mouseStk3 protein, mouseStk4 protein, mouseLiver injuryMST1/2 DKO,· Salvianolic acid BpSmad2C/pSmad2L

Identifiers

PMID40220025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.