Evidence map›Paper›PMID 40219922›Full record

ArticleChemistry & biodiversity2025

Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential.

Giovana G F V de Oliveira, Milena F Longue, Letícia M R Pescinelli, Thiago S Charret, Thalya S R Nogueira, Mariana T M Pereira, Ivo J C Vieira, Lucas S Abreu, Vinicius D B Pascoal, Aislan C R F Pascoal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovana G F V de OliveiraResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Milena F LongueResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Letícia M R PescinelliResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Thiago S CharretResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Thalya S R NogueiraLaboratory of Chemical Sciences, Center for Exact Sciences and Technology, State University of North Fluminense Darcy Ribeiro-UENF, Campos dos Goytacazes, Brazil.
Mariana T M PereiraResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Ivo J C VieiraLaboratory of Chemical Sciences, Center for Exact Sciences and Technology, State University of North Fluminense Darcy Ribeiro-UENF, Campos dos Goytacazes, Brazil.
Lucas S AbreuNatural Products Chemistry Laboratory, Institute of Chemistry, Fluminense Federal University- UFF, Niteroi, Brazil.
Vinicius D B PascoalResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.
Aislan C R F PascoalResearch Laboratory of Natural Products and Bioactive Molecules, Nova Friburgo Health Institute, Fluminense Federal University-UFF, Nova Friburgo, Brazil.ORCID https://orcid.org/0000-0002-4234-4843

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work evaluated the antiproliferative potential of Eugenia brasiliensis leaf extracts against the HeLa cervical cancer cell line. The extracts were prepared by maceration using hexane (EBH), dichloromethane (EBD), and ethyl acetate (EBAE), and they were evaluated for their antiproliferative potential through a 3-4,5-dimethyl-thiazol-2-yl-2,5-diphenyltetrazoliumbromide (MTT) assay in the cervical cancer cell culture (HeLa cell line) and a non-cancer cell line (NIH-3T3). EBH, EBD, and EBAE were cytotoxic in HeLa cells, with 50% inhibition concentration (IC

Indexed as

Antineoplastic Agents, PhytogenicEugeniaPlant ExtractsAnimalsCell CycleCell MovementCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHeLa CellsHumansMiceMolecular StructureNIH 3T3 CellsPlant LeavesAntineoplastic Agents, PhytogenicPlant Extractsbiological activitiesMyrtaceaenatural products

Identifiers

PMID40219922
PMCPMC12435421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.