Evidence map›Paper›PMID 40219820›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2025

Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.

Mai Thi Quynh Le, Kumiko Yoshimatsu, Haruka Abe, Thuy Thi Nguyen, Hang Le Khanh Nguyen, Trang Thi Hong Ung, Phuong Vu Mai Hoang, Nobuo Koizumi, Futoshi Hasebe, Kozue Miura

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In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mai Thi Quynh LeDepartment of Virology, National Institute of Hygiene and Epidemiology, Hai Ba Trung district, Hanoi 10000, Vietnam.
Kumiko YoshimatsuLaboratory of Animal Experimentation, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Haruka AbeVietnam Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Thuy Thi NguyenDepartment of Virology, National Institute of Hygiene and Epidemiology, Hai Ba Trung district, Hanoi 10000, Vietnam.
Hang Le Khanh NguyenDepartment of Virology, National Institute of Hygiene and Epidemiology, Hai Ba Trung district, Hanoi 10000, Vietnam.
Trang Thi Hong UngDepartment of Virology, National Institute of Hygiene and Epidemiology, Hai Ba Trung district, Hanoi 10000, Vietnam.
Phuong Vu Mai HoangDepartment of Virology, National Institute of Hygiene and Epidemiology, Hai Ba Trung district, Hanoi 10000, Vietnam.
Nobuo KoizumiDepartment of Bacteriology I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Futoshi HasebeVietnam Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Kozue MiuraDepartment of Veterinary Medical Sciences, Graduate school of Agricultural and Life Sciences, the University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.ORCID 0000-0002-3233-0202

Funding

Global Research Infrastructure, Collaborative Research via Overseas Research Centers JP23wm0125006Japan Agency for Medical Research and Development JP24fk0108638Nagasaki University Institute of Tropical Medicine 2023-Kyoten-06
6 · The paper itself

Abstract

backgroundDengue fever has surged in Vietnam since 2021; however, the aetiology of non-dengue undifferentiated febrile illnesses remains poorly understood.

methodsFifty whole blood samples that tested negative in rapid tests for anti-dengue virus antibodies (IgM and IgG) and NS1 viral antigen at Vung Tau General Hospital, southern Vietnam, were subjected to nucleic acid amplification tests for flaviviruses, hantaviruses, Leptospira spp. and Orientia tsutsugamushi, followed by DNA sequencing. The plasma samples were also tested for anti-hantavirus IgM and IgG antibodies using ELISA.

resultsOf the 50 samples, eight were PCR-positive for flaviviruses and two were positive for hantaviruses. Sequencing analysis revealed that three and five of the eight flavivirus-positive samples were dengue virus type 1 and dengue virus type 2, respectively. The hantavirus species was identified as Orthohantavirus seoulense (SEOV). None of the patients tested positive for Leptospira spp. or O. tsutsugamushi. Anti-hantavirus IgM and IgG antibodies were detected in five and four patients, respectively.

conclusionsThis study suggests that SEOV is a notable contributor to dengue-negative febrile illnesses in southern Vietnam. ACCESSION NUMBER: LC822654.

Indexed as

DengueHantavirus InfectionsSeoul virusAdolescentAdultAntibodies, ViralDengue VirusEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedVietnamYoung AdultAntibodies, ViralImmunoglobulin GImmunoglobulin Mdengue feverhantavirusOrthohantavirus seoulenseundifferentiated febrile illnessVietnam

Identifiers

PMID40219820
PMCPMC12403207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.