ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Changing definitions of disease: Transformations in the diagnostic criteria for Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Just Semantics? How Diagnostic Criteria Influence Physician-Patient Narratives in Alzheimer's Disease.Neuro-degenerative diseases · 2026Article
- Defining Alzheimer's disease: stipulations and the ethics of diagnostic change.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Amyloid-beta statuses prediction with free water MR imaging features in Alzheimer's disease using machine learning models.BMC medical imaging · 2026Article
- The evolution of disease criteria in multiple sclerosis: underlying motives and broader implications.BMC neurology · 2026Article
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Changing definitions of disease: Transformations in the diagnostic criteria for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer Disease.Alzheimer disease and associated disordersArticle
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Abstract
introductionWhether Alzheimer's disease (AD) should be defined by symptoms, biological processes, or both, is a matter of debate. We aim to reconstruct the motivations, aims, and content of consecutive versions of AD diagnostic criteria.
methodsWe systematically analyzed publications on AD diagnostic criteria between 1984 and 2024.
resultsEarly diagnosis and incorporating recent scientific findings are recurring aims for criteria revisions but aims and motivations for revising are often unclear or ambiguous and reflection on previous criteria is lacking. The subsequent criteria, except International Working Group (IWG) 2021/2024, consistently lower the threshold for diagnosing AD and increasingly focus on amyloid β and tau biomarkers. DISCUSSION: Subsequent AD criteria show an increasing "biomarkerization," but it is often unclear what problems revised criteria should solve and how effective they are. To overcome these limitations, future revisions should evaluate the effectiveness and impacts of previous criteria, and define clear problems and aims. HIGHLIGHTS: Early diagnosis and incorporating scientific insights are recurring aims. The aims of new criteria are often not clearly articulated or ambiguous. The number of requirements for an AD diagnosis decreases over time. Consecutive criteria for research and clinical use did not result in clear terminology. The AD definition is increasingly narrowed to amyloid β and tau.
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