Evidence map›Paper›PMID 40219547›Full record

ArticlemAbs2025

Recommended nomenclature convention for the NISTCHO cell line and its product monoclonal antibody, cNISTmAb.

Megan H Cleveland, Ioannis L Karageorgos, John P Marino, Michael J Tarlov, Katharina S Yandrofski, Rebecca A Zangmeister, Zvi Kelman

Abstract read
In one paragraph

Article in mAbs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan H ClevelandBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0002-5584-9314
Ioannis L KarageorgosBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0002-2799-766X
John P MarinoBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0002-6860-5853
Michael J TarlovBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0001-7384-5264
Katharina S YandrofskiBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0002-0570-8011
Rebecca A ZangmeisterBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0002-0540-6240
Zvi KelmanBiomolecular Measurement Division, National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.ORCID 0000-0003-4774-3963

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NISTCHO is a Chinese hamster ovary (CHO) cell line expressing the same amino acid sequences as the heavy and light chains of the National Institute of Standards and Technology (NIST) monoclonal antibody [Reference Material (RM) 8671 NISTmAb]. NISTCHO was generated by MilliporeSigma to be developed by NIST as a RM to support biomanufacturing research and innovation, method development and qualification, and pre-competitive research collaboration. The RM cell line, denoted as RM 8675 NISTCHO, Clonal CHO-K1 Cell Line Producing cNISTmAb, is of interest to the biopharmaceutical and biomanufacturing industries, regulatory and government agencies, and academic institutions. In contrast to other NIST RMs, however, which are typically discrete and finite, the NISTCHO is a living RM that can be propagated, expanded, and used repeatedly to express the non-originator NISTmAb product, cNISTmAb. Therefore, a uniform naming convention should be adopted by the user community to best track the origins of materials (the cell line and products) used in studies derived from the RM 8675 NISTCHO. Here, we provide a naming convention for the derivatives of the RM 8675 NISTCHO and the cNISTmAb produced by these NISTCHO derivatives and recommend these naming conventions for adoption by the scientific community.

Indexed as

Antibodies, MonoclonalTerminology as TopicAnimalsCHO CellsCricetinaeCricetulusHumansAntibodies, Monoclonalchinese hamster ovary (CHO)cNISTmAbnaming conventionNISTCHONIST RMreference material

Identifiers

PMID40219547
PMCPMC12005425

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.