ArticlePolymers2025
Development of a Photocrosslinkable Collagen-Bone Matrix Hydrogel for Bone Tissue Engineering.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Regenerative potential of Schneiderian membrane-derived mesenchymal stem cells in sinus floor elevation model and calvarial defect model.Journal of Zhejiang University. Science. B · 2026Article
- The Collapse of the Collagen Sponge Microstructure Triggers an Inflammatory Response of Macrophages via theBioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Bone tissue engineering aims to restore lost bone and create an environment conducive to new bone formation. To address this challenge, we developed a novel biomimetic hydrogel that combines maleic anhydride-modified type I collagen (ColME) with maleic anhydride-modified demineralized and decellularized porcine bone matrix particles (mDBMp), forming a composite ColME-mDBMp (CMB) hydrogel. Chemical modification of collagen resulted in a high degree of substitution, thereby enhancing its photocrosslinkability. Integration of mDBMp into the ColME hydrogel via photocrosslinking resulted in enhanced physiological stability, reduced shrinkage, and improved mechanical strength compared to gelatin methacrylate (GelMA)-based hydrogels. Moreover, mineralization of the CMB hydrogel promoted the formation of pure hydroxyapatite (HAp) crystals, providing superior stiffness while maintaining ductility relative to GelMA-based hydrogels. In vitro, human bone marrow mesenchymal stem cells (hBMSCs) encapsulated in CMB hydrogels exhibited enhanced proliferation, cell-matrix interactions, and osteogenic differentiation, as evidenced by increased calcium deposition and histological analysis. These results demonstrate that the CMB hydrogel, enriched with extracellular matrix (ECM) components, shows considerable promise over current GelMA-based hydrogels for bone tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.