Evidence map›Paper›PMID 40219244›Full record

ReviewPolymers2025

Toward Sustainable Polyhydroxyalkanoates: A Next-Gen Biotechnology Approach.

Vipin Chandra Kalia, Rahul Vikram Singh, Chunjie Gong, Jung-Kul Lee

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Advances in Polyhydroxyalkanoate (PHA) Production, Volume 4.Bioengineering (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vipin Chandra KaliaDepartment of Chemical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.ORCID 0000-0001-7892-2601
Rahul Vikram SinghDepartment of Chemical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.ORCID 0000-0002-5724-719X
Chunjie GongCooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China.ORCID 0000-0003-2198-6342
Jung-Kul LeeDepartment of Chemical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.ORCID 0000-0001-7384-5301

Funding

National Research Foundation of Korea 2022M3A9I3082366National Research Foundation of Korea 2022M3A9I5015091National Research Foundation of Korea RS-2024-00351665National Research Foundation of Korea RS-2024-00440681
6 · The paper itself

Abstract

Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers synthesized by microorganisms and serve as sustainable alternatives to petroleum-based plastics. While traditional PHA production relies on refined carbon sources and pure cultures, high costs and scalability challenges limit commercial viability. Extremophiles, particularly halophiles, have emerged as promising candidates for cost-effective, large-scale production of PHAs. Their ability to thrive in extreme environments reduces contamination risks, minimizes the need for sterilization, and lowers operational costs. Advancements in metabolic engineering, synthetic biology, and CRISPR-based genome editing have enhanced PHA yields by optimizing metabolic flux and cell morphology. Additionally, utilizing alternative feedstocks such as biowaste, syngas, methane, and CO₂ improves economic feasibility. Next-generation industrial biotechnology integrates extremophilic microbes with AI-driven fermentation and eco-friendly downstream processing to enhance scalability. Industrial-scale production of PHAs using

Indexed as

environmental sustainabilityextremophilesgreen technologyindustrial biotechnologyindustrial waste valorizationpolyhydroxyalkanoatespolymers

Identifiers

PMID40219244
PMCPMC11991626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.