Caffeine Combined with Excitatory Neuromodulation Based on Transcranial Direct Current Stimulation (tDCS) Enhances Performance in a Time-Trial CrossFit
Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Alberto Souza Sá FilhoDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-9434-4231
Thiago Albernaz-SilvaDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.
Pedro Augusto InacioDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-9354-1460
Vicente ApriglianoEscuela de Ingeniería de Construcción y Transporte, Pontificia Universidad Católica de Valparaíso, Avda Brasil 2147, Valparaíso 2362804, Chile.ORCID 0000-0002-7285-2742
Iransé Oliveira-SilvaDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.
Gaspar R ChiappaDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-0440-8404
Rodolfo P VieiraDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-6379-1143
Antônio Sérgio Nakao de AguiarDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.
Raphael Martins CunhaDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-3938-2734
James Oluwagbamigbe FajemiroyeDepartment of Human Movement and Rehabilitation (PPGMHR) and Pharmaceutical Sciences, Pharmacology and Therapeutics (PPGCFFT), Graduate Program at the Evangelical University of Goiás (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-7440-7581
Marcelo Magalhães SalesGraduate Program in Environmental and Society, Academic Institute of Health and Biological Sciences, State University of Goiás, Southwest Campus, Quirinópolis 75862-196, GO, Brazil.ORCID 0000-0003-3814-6964
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundCaffeine (CAF) and transcranial direct current stimulation (tDCS) are ergogenic strategies with potential benefits for performance, yet their combined effects remain underexplored, particularly in high-intensity functional training contexts such as CrossFit
methodsTwenty participants completed four experimental conditions: CAF ingestion (400 mg) combined with anodal tDCS (CAF + a-tDCS), CAF with Sham tDCS (CAF + Sham-tDCS), placebo (PLA) with a-tDCS (PLA + a-tDCS), and PLA with Sham tDCS (PLA + Sham-tDCS).
resultsThe results indicated that the combination of CAF + a-tDCS significantly improved performance, reducing execution time (205.5 ± 58.0 s) compared to CAF + Sham-tDCS (218.3 ± 61.2 s;
conclusionsThe responder analysis revealed that 45% of participants improved performance with isolated tDCS, while 60% responded positively to CAF. No significant differences were found in RPE scores among conditions (
Indexed as
Athletic PerformanceCaffeinePerformance-Enhancing SubstancesTranscranial Direct Current StimulationAdultAthletesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleYoung AdultCaffeinePerformance-Enhancing SubstancesCrossFit®HIFThigh-intensity functional trainingHIITperformancetDCS
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Caffeine Combined with Excitatory Neuromodulation Based on Transcranial Direct Current Stimulation (tDCS) Enhances Performance in a Time-Trial CrossFit · full record | OpenQuestion