Evidence map›Paper›PMID 40218974›Full record

ArticleNutrients2025

Preliminary Evidence Suggests That a 12-Week Treatment with Tirzepatide Plus Low-Energy Ketogenic Therapy Is More Effective than Its Combination with a Low-Calorie Diet in Preserving Fat-Free Mass, Muscle Strength, and Resting Metabolic Rate in Patients with Obesity.

Luigi Schiavo, Biagio Santella, Monica Mingo, Gianluca Rossetti, Marcello Orio, Luigi Cobellis, Attilio Maurano, Antonio Iannelli, Vincenzo Pilone

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Article
  4. Nutrition Strategies for Next-Generation Incretin Therapies: A Systematic Scoping Review of the Current Evidence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luigi SchiavoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-3639-6847
Biagio SantellaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0002-5010-1390
Monica MingoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Gianluca RossettiGeneral and Bariatric Surgery Unit, Abano Terme Policlinic, 35031 Padova, Italy.
Marcello OrioMedical and Diabetological Center CMSO, 84123 Salerno, Italy.
Luigi CobellisUnit of General Surgery, Casa Di Cura "Prof. Dott. Luigi Cobellis", 84078 Vallo della Lucania, Italy.
Attilio MauranoDigestive Endoscopic Unit, Ruggiero Clinic, 84013 Cava de Tirreni, Italy.
Antonio IannelliDigestive Surgery and Liver Transplantation Unit, Archet 2 Hospital, Centre Hospitalier Universitaire de Nice, 06001 Nice, France.
Vincenzo PilonePublic Health Department, University of Naples Federico II, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Basal MetabolismCaloric RestrictionDiet, KetogenicMuscle StrengthObesityAdultBody CompositionFemaleHumansMaleMiddle AgedProspective StudiesTirzepatideTreatment OutcomeWeight LossTirzepatidebody compositionlow-energy ketogenic therapymuscle strengthobesityresting metabolic ratetirzepatide

Identifiers

PMID40218974
PMCPMC11990520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.