Evidence map›Paper›PMID 40218962›Full record

ArticleNutrients2025

Circadian Regulation of Vitamin D Target Genes Reveals a Network Shaped by Individual Responsiveness.

Parcival Maissan, Carsten Carlberg

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Parcival MaissanInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-683 Olsztyn, Poland.ORCID 0009-0009-6961-7109
Carsten CarlbergInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-683 Olsztyn, Poland.ORCID 0000-0003-2633-0684

Funding

European Union's Horizon 2020 research and innovation program 952601European Union's Horizon Europe research and innovation program 101119497
6 · The paper itself

Abstract

backgroundIn humans, vitamin D

resultsAs part of the VitDHiD intervention study, we identified 87 in vivo vitamin D target genes with circadian expression patterns in immune cells, forming a regulatory network centered on transcription factors and membrane receptors. These genes exhibit a narrow basal expression range, with 80% downregulated upon vitamin D

conclusionsThese findings highlight a novel link between vitamin D signaling and circadian gene regulation, with potential implications for personalized supplementation strategies.

Indexed as

CholecalciferolCircadian RhythmGene Expression RegulationGene Regulatory NetworksVitamin DAdultDietary SupplementsFemaleHumansMaleReceptors, CalcitriolTranscription FactorsCholecalciferolReceptors, CalcitriolTranscription FactorsVitamin Dcircadian gene regulationdifferential gene expressiontranscriptomevitamin Dvitamin D receptorvitamin D target genes

Identifiers

PMID40218962
PMCPMC11990303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.