Evidence map›Paper›PMID 40218866›Full record

ArticleNutrients2025

Omega-3 EPA Supplementation Shapes the Gut Microbiota Composition and Reduces Major Histocompatibility Complex Class II in Aged Wild-Type and APP/PS1 Alzheimer's Mice: A Pilot Experimental Study.

Barbara Altendorfer, Ariane Benedetti, Heike Mrowetz, Sabine Bernegger, Alina Bretl, Julia Preishuber-Pflügl, Diana Marisa Bessa de Sousa, Anja Maria Ladek, Andreas Koller, Pauline Le Faouder and 3 more

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Omega-3 polyunsaturated fatty acids and gut microbiota.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Barbara AltendorferInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0003-3669-5206
Ariane BenedettiInstitute of Experimental Neuroregeneration, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0009-0003-6855-6507
Heike MrowetzInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0009-0003-8373-6813
Sabine BerneggerInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0002-0164-2537
Alina BretlInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
Julia Preishuber-PflüglResearch Program for Experimental Ophthalmology and Glaucoma Research, Department of Ophthalmology and Optometry, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0009-0000-4716-908X
Diana Marisa Bessa de SousaInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
Anja Maria LadekResearch Program for Experimental Ophthalmology and Glaucoma Research, Department of Ophthalmology and Optometry, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Andreas KollerResearch Program for Experimental Ophthalmology and Glaucoma Research, Department of Ophthalmology and Optometry, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0001-6108-8411
Pauline Le FaouderMetaToul-Lipidomique Core Facility, I2MC, Inserm 1048, 31432 Toulouse, France.
Justine Bertrand-MichelMetaToul-Lipidomique Core Facility, I2MC, Inserm 1048, 31432 Toulouse, France.ORCID 0000-0001-9815-1517
Andrea TrostResearch Program for Experimental Ophthalmology and Glaucoma Research, Department of Ophthalmology and Optometry, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Ludwig AignerInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0002-1653-8046

Funding

PMU-Research and Innovation Fund 2023-PRE-008-Altendorfer
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseDietary SupplementsEicosapentaenoic AcidGastrointestinal MicrobiomeGenes, MHC Class IIHistocompatibility Antigens Class IIAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalFatty Acids, Omega-3FemaleHippocampusMiceMice, TransgenicPilot ProjectsAmyloid beta-Protein PrecursorEicosapentaenoic AcidFatty Acids, Omega-3Histocompatibility Antigens Class IIAlzheimer’s diseaseAPP/PS1eicosanoidseicosapentaenoic acid (EPA)gut microbiotalipid dropletsMHCIImicrogliaomega-3 polyunsaturated fatty acidsphagocytosis

Identifiers

PMID40218866
PMCPMC11990804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.