Evidence map›Paper›PMID 40218376›Full record

ArticleAnimals : an open access journal from MDPI2025

Dietary Glyceryl Polyethylene Glycol Ricinoleate as an Additive to Improve Intestinal Health in Post-Weaning Piglets.

Julieta M Decundo, Susana N Dieguez, Guadalupe Martínez, Fabián A Amanto, María L Maté, Juan P Lirón, Denisa S Pérez Gaudio, Carolina P Bianchi, Aurélie Montagnon, Alejandro L Soraci

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julieta M DecundoLaboratorio de Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina.ORCID 0000-0002-2433-1846
Susana N DieguezLaboratorio de Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina.ORCID 0009-0001-3827-6526
Guadalupe MartínezLaboratorio de Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina.ORCID 0000-0003-2551-2902
Fabián A AmantoÁrea de Producción Porcina, Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia, Tandil 7000, Argentina.
María L MatéLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CICPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro (FCV-UNCPBA), Tandil 7000, Argentina.
Juan P LirónLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CONICET-CICPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro (FCV-UNCPBA), Tandil 7000, Argentina.ORCID 0000-0002-1989-8733
Denisa S Pérez GaudioLaboratorio de Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina.ORCID 0000-0003-2179-7760
Carolina P BianchiFacultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET), Tandil 7000, Argentina.ORCID 0000-0002-9052-8356
Aurélie MontagnonOrffa Additives B.V., 4817 ZL Breda, The Netherlands.
Alejandro L SoraciLaboratorio de Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil 7000, Argentina.

Funding

CIVETAN-CONICET STAN 3991
6 · The paper itself

Abstract

Early weaning in intensive pig production induces stress, compromising gastrointestinal health. Poor fat digestion results from the piglets' underdeveloped digestive system. Dietary emulsifiers can enhance fat utilization, and glyceryl polyethylene glycol ricinoleate (GPGR) has been shown to improve pig performance. This study evaluated GPGR's effects on intestinal health in weaned piglets in a commercial production farm. A total of 380 just weaned (21 days old) piglets were divided in two groups of 190 animals each (in four replicates) that received either a basal diet (control) or a basal diet + 350 g/ton GPGR pharmaceutical formulation as top dress. Blood samples were collected at pre-established days, and intestinal sampling occurred 15 days post-weaning. Plasma cortisol, citrulline, intestinal morphology, mucus quality, enzymatic activity, volatile fatty acids (VFAs), and cecal microbiota were analyzed. GPGR did not alter plasma cortisol but increased citrullinemia (P: 0.024), suggesting greater enterocyte functional mass. GPGR piglets showed improved intestinal morphology (greater villus height, villus height:crypt depth ratio, and intestinal absorption area,

Indexed as

emulsifiergastrointestinal tractglyceryl polyethylene glycol ricinoleatemicrobiotapigweaning stress

Identifiers

PMID40218376
PMCPMC11988148

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.