Evidence map›Paper›PMID 40218328›Full record

ReviewAnimals : an open access journal from MDPI2025

Research Status and Prospect of Amphibian Symbiotic Microbiota.

Ziyi Wang, Yuting Wang, Zhirong He, Siyu Wu, Suyue Wang, Na Zhao, Wei Zhu, Jianping Jiang, Supen Wang

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Gut and skin microbiota ofFrontiers in microbiology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziyi WangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Yuting WangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Zhirong HeThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Siyu WuThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Suyue WangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.
Na ZhaoThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.ORCID 0000-0001-9523-6072
Wei ZhuChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Jianping JiangChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.ORCID 0000-0002-1051-7797
Supen WangThe Anhui Provincial Key Laboratory of Biodiversity Conservation and Ecological Security in the Yangtze River Basin, College of Life Sciences, Anhui Normal University, Wuhu 241000, China.ORCID 0000-0002-9522-9005

Funding

China Postdoctoral Science Foundation 2022M723135the National Natural Science Foundation of China 31901120 and 31700320
6 · The paper itself

Abstract

Amphibians are the most severely threatened vertebrate group in terms of biodiversity. The microbiota that coexist in a mutualistic relationship with amphibians play a crucial role in shaping their health status, reproductive efficiency, and environmental adaptability. Understanding the relationship between amphibians and microbiota is vital for elucidating the causes of amphibian diseases and developing effective prevention and control techniques, which in turn is significant for enhancing the effectiveness of amphibian diversity conservation. The main findings of this article are as follows: Firstly, it provides an overview of the systematic assessment and analysis methods regarding the importance of amphibians and their symbiotic microbiota, detailing the primary research techniques currently employed. Secondly, it discusses the impacts of environmental and biological factors on the characteristics of amphibian symbiotic microbial communities, including dimensions such as altitude, temperature fluctuations, and host dietary habits. Finally, the future directions of research on amphibian symbiotic microbiota are examined, with five recommendations presented: (1) Establish a comprehensive sample library and database of amphibians and their symbiotic microbiota to create a solid foundation for scientific research. (2) Explore the coevolutionary paths between amphibians and symbiotic microbiota to clarify the dynamic evolutionary patterns and principles of their interactions. (3) Strengthen research on specific areas of amphibians, especially the microbial communities in the oral cavity and cloaca. (4) Enhance research on the symbiotic microbiota of the Gymnophiona. (5) Strengthen international cooperation to build cross-border research platforms and jointly promote the rapid development of global amphibian symbiotic microbiology. This article summarizes the current research progress on the interaction between amphibians and their symbiotic microbiota (not necessarily mutualistic). It discusses the conservation of amphibian biodiversity from the perspective of their symbiotic microbial communities and provides a forward-looking analysis of future research directions. It aims to provide rich background information for understanding the complexity of this symbiotic system, while also having significant value in enhancing the effectiveness of amphibian biodiversity conservation.

Indexed as

amphibiansbiodiversitygut microbiotaskin microbiotasymbiotic microbiota

Identifiers

PMID40218328
PMCPMC11987896

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.