Repurposing Vancomycin as a Potential Antiviral Agent Against PEDV via nsp13 Helicase Inhibition.

Qiao Chen, Mengqi Yu, Jiajing Guo, Jingqi Qiu, Fei Liu, Yanke Shan

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiao ChenJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Mengqi YuJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Jiajing GuoJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Jingqi QiuJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Fei LiuJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Yanke ShanJoint International Research Laboratory of Animal Health and Food Safety of Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China.

Funding

China Postdoctoral Science Foundation 2020M681649China Postdoctoral Science Foundation 2020T130055ZXFundamental Research Funds for the Central Universities KYT2024004National Natural Science Foundation of China 32000028

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) causes a highly contagious intestinal disease with severe economic impacts on the global swine industry. The non-structural protein 13 (nsp13), a viral helicase, is essential for viral replication, making it a promising target for antiviral drug development. In this study, through virtual screening and molecular dynamics simulations, Vancomycin, a small-molecule drug also clinically used as an antibacterial agent, was identified to exhibit a stable binding affinity for PEDV nsp13. The NTPase and ATP-dependent RNA helicase activities of PEDV nsp13 were confirmed

Indexed as

antiviral drughelicase inhibitornsp13porcine epidemic diarrhea virusvancomycinvirtual screening

Identifiers

PMID40218318

DOI10.3390/ani15070923

PMCPMC11987754

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.