Evidence map›Paper›PMID 40218001›Full record

ArticleHealthcare (Basel, Switzerland)2025

Associations of Dietary Zinc Supplementation and Sleep Patterns with Chronic Kidney Disease Risk: A Prospective Cohort Study.

Xiaofeng Zhang, Shuai Zhang, Jiali Lv, Xiaoyan Ma, Xia Lin, Lin Yang, Shengxu Li, Tao Zhang

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaofeng ZhangDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Shuai ZhangDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Jiali LvDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xiaoyan MaDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xia LinDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Lin YangDepartment of Cancer Epidemiology and Prevention Research, Cancer Research & Analytics, Cancer Care Alberta, Alberta Health Services, Calgary, AB T2V 0N5, Canada.ORCID 0000-0002-1698-6666
Shengxu LiChildren's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN 55404, USA.ORCID 0000-0001-9210-7283
Tao ZhangDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID 0000-0003-1048-4443

Funding

National Natural Science Foundation of China 82222064National Natural Science Foundation of China T2321004
6 · The paper itself

Abstract

backgroundPrevious studies have indicated that both dietary zinc supplementation and sleep patterns may influence the development of chronic kidney disease (CKD). Additionally, it is established that dietary zinc can enhance sleep quality. Despite these insights, the interplay between zinc supplementation and sleep patterns, and their combined effect on CKD progression, is still not fully understood.

methodsThis population-based cohort study used UK Biobank data (2006-2010) and employed cox regression models to assess the associations between dietary zinc supplementation, sleep patterns, and their combined effects on CKD.

resultsOver a median follow-up of 14.8 years, 22,384 new CKD cases were identified. Zinc supplementation reduced CKD risk in individuals with poor (HR: 0.70, 95% CI: 0.50-0.98) and moderate (HR: 0.89, 95% CI: 0.81-0.98) sleep patterns but not in those with healthy sleep (HR: 1.00, 95% CI: 0.89-1.14). A significant interaction between zinc supplementation and sleep patterns was observed (

conclusionsThese findings indicate a significant association between dietary zinc supplementation and reduced CKD risk, especially in individuals with poor sleep patterns. Further studies are needed to explore zinc supplementation as a targeted intervention for those at higher CKD risk due to poor sleep.

Indexed as

chronic kidney diseasedietary zinc supplementationprospective cohort studysleep patternszinc–sleep interaction

Identifiers

PMID40218001
PMCPMC11988376

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.