ReviewJournal of activity, sedentary and sleep behaviors2023
The associations between physical activity, sedentary behaviour, and sleep with mortality and incident cardiovascular disease, cancer, diabetes and mental health in adults: a systematic review and meta-analysis of prospective cohort studies.
Review in Journal of activity, sedentary and sleep behaviors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity, screen time and sleep among children and adolescents: findings from the 2022 active healthy kids Ethiopia.BMC pediatrics · 2025Pooled it
- Behavioral and Contextual Patterns Derived From Ecological Momentary Assessment and Wearable Sensors and Their Associations With Health-Related Outcomes: WEALTH Cross-Sectional Study.JMIR formative research · 2026Article
- Insomnia as an Independent Behavioral Correlate of Estimated Type 2 Diabetes Risk: Evidence from Three Validated Risk Assessment Scales.Rambam Maimonides medical journal · 2026Article
- Associations between leisure-time physical activity and sleep problems among 11 346 Danish adults: the moderating role of stress.European journal of public health · 2026Article
- Revisiting the social determinants of health with explainable AI: a cross-country perspective.American journal of epidemiology · 2026Article
- Article
- Components of 24-hour movement behavior and self-reported physical fitness in Ibero-American preschoolers, children, and adolescents during the COVID-19 pandemic.Frontiers in public health · 2026Article
- Game over: dissecting the overlooked health harms of modern sports.Frontiers in sports and active living · 2026Review
- Associations between eHealth literacy and 24-hour movement behaviors in older adults: the mediating and moderating roles of self-efficacy.Frontiers in medicine · 2026Article
- Adherence to the 24-Hour Movement Guidelines is related to a lower risk of all-cause mortality: A prospective cohort study of 14,288 participants from the SUN Project.Journal of sport and health science · 2025Article
- The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Indigenous games and physical activity for preventing non-communicable diseases in African communities: a public health perspective.Frontiers in sports and active living · 2025Review
- Isotemporal substitution analysis of time between sedentary behavior, and physical activity on sleep quality in younger adults: a multicenter study.BMC public health · 2024Article
- Regularity of bedtime, wake-up time, and time in bed in mid-life: associations with cardiometabolic health markers with adjustment for physical activity and sedentary time.Journal of activity, sedentary and sleep behaviors · 2024Article
- 24-hour movement behavior adherence and associations with health outcomes: an umbrella review.Journal of activity, sedentary and sleep behaviors · 2024Review
- The associations between physical activity, sedentary behaviour, and sleep with mortality and incident cardiovascular disease, cancer, diabetes and mental health in adults: a systematic review and meta-analysis of prospective cohort studies.Journal of activity, sedentary and sleep behaviors · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPhysical activity, sedentary behaviour and sleep are interrelated and may have a synergistic impact on health. This systematic review and meta-analysis of prospective cohort studies aimed to evaluate the combined influence of different combinations of these behaviours on mortality risk and incidence of cardiovascular disease (CVD), cancer, diabetes, and mental health.
methodsFour online databases were used to identify studies from database inception to May 2023. Prospective cohort studies that examined how different combinations of physical activity, sedentary and sleep behaviours were associated with mortality and incident cardiovascular disease, cancer, diabetes and mental health in adults were included. Random effects meta-analyses using the Der Simonian and Laird method were conducted.
resultsAssessment of 4583 records resulted in twelve studies being included. Studies were qualitatively summarised and a sub-group of studies (n = 5) were meta-analysed. The most frequent combination of behaviours was duration of leisure time physical activity and sleep (n = 9), with all-cause mortality (n = 16), CVD mortality (n = 9) and cancer mortality (n = 7) the most frequently examined outcomes. Meta-analysis revealed that relative to High physical activity & Mid sleep, High physical activity and Short sleep was not associated with risk of all-cause mortality (RR = 1.05, 95% CI = 0.97, 1.14), however Low physical activity and Short Sleep (RR = 1.42, 95% CI = 1.24, 1.63), Low physical activity and Mid Sleep (RR = 1.30, 95% CI = 1.12, 1.52), High physical activity and Long Sleep (RR = 1.16, 95% CI = 1.01, 1.32), and Low physical activity and Long Sleep were associated with risk of all-cause mortality (RR = 1.63, 95% CI = 1.21, 2.20).
conclusionsHigh levels of physical activity may offset all-cause mortality risks associated with short sleep duration. Low levels of physical activity combined with short sleep duration and any level of physical activity in combination with long sleep duration appear to increase mortality risk. Currently there is limited evidence regarding how dimensions of physical activity, sedentary and sleep behaviours other than duration (e.g., quality, timing, type) are associated with future health status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.