Evidence map›Paper›PMID 40217494›Full record

ArticleThrombosis journal2025

Tissue factor, factor VIII and IX in microvesicle-induced thrombosis and tumor growth of pancreatic cancer.

Sheng-Chieh Chou, Shu-Lun Chang, Cheng-Yeh Yu, Chao-I Lin, Yen-Ting Chang, Li-Fu Chen, Jia-Yi Li, Chen-Hsueh Pai, Shu-Rung Lin, Wern-Cherng Cheng and 2 more

Abstract read
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In one paragraph

Article in Thrombosis journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheng-Chieh ChouDivision of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-4121-019X
Shu-Lun ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Cheng-Yeh YuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Chao-I LinDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Yen-Ting ChangDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Li-Fu ChenDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Jia-Yi LiDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Chen-Hsueh PaiDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.
Shu-Rung LinDepartment of Bioscience Technology, College of Science, Chung-Yuan Christian University, Taoyuan, Taiwan.
Wern-Cherng ChengDepartment of Laboratory Medicine, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Chang-Tsu YuanDepartment of Pathology, National Taiwan University Cancer Center, Taipei, Taiwan.
Shu-Wha LinDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan. mtshuwha@ntu.edu.tw.ORCID http://orcid.org/0000-0001-6748-5581

Funding

National Science and Technology Council 105-2320-B-002-052-MY3, MOST 108-2320-B-002-051-MY3, MOST 111-2740-B-002-004, NSTC 112-2740-B-002-002National Taiwan University Hospital 111-S0033
6 · The paper itself

Abstract

backgroundTissue factor (TF)-rich cancer microvesicles are correlated with thrombosis risk. Intrinsic coagulation factors are also associated with the risk of thrombosis in cancer patients. This study explored the roles of pancreatic cancer-derived microvesicles and intrinsic factors in thrombogenesis.

methodsHuman pancreatic cancer cell lines rich in TF (AsPC-1-TF

resultsWith the injection of TF

conclusionPancreatic cancer thrombosis induced by TF-expressing microvesicles strongly depended on FVIII and FIX, while VWF played a minor role. Moreover, TF, but not FVIII, was significantly related to tumor growth.

Identifiers

PMID40217494
PMCPMC11987238

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