Evidence map›Paper›PMID 40217470›Full record

ArticleBMC anesthesiology2025

Apneic oxygenation with Transnasal Humidified Rapid-insufflation Ventilator Exchange (THRIVE) in obstructive sleep apnea patients: study protocol of a randomized controlled trial.

Guiyu Lei, Lili Wu, Chunhua Xi, Siliu Yang, Qingwen Yang, Shaofei Su, Guyan Wang

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06581588 (Apnoeic Oxygenation in Obstructive Sleep Apnea), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06581588 nacompletednot on this map

Apnoeic Oxygenation in Obstructive Sleep Apnea: a Randomised Controlled Trial Comparing Transnasal Humidified Rapid Insufflation Ventilator Exchange (THRIVE) Combined With Nasopharyngeal Airway and THRIVE Alone

TypeinterventionalSponsorBeijing Tongren HospitalRan2024 to 2025Enrolled56ConditionsObstructive Sleep Apnea SyndromeArmsTHRIVE, THRIVE combine nasopharyngeal airway
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guiyu LeiDepartment of Anaesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Lili WuDepartment of Anaesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Chunhua XiDepartment of Anaesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Siliu YangDepartment of Anesthesiology, Beijing Dongcheng Maternal and Child Health Care Hospital, Beijing, 100007, China.
Qingwen YangDepartment of Otolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education of China), Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Shaofei SuCentral Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Chaoyang, Beijing, 100026, China.
Guyan WangDepartment of Anaesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. guyanwang2006@163.com.

Funding

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support 、 (No. ZYLX202103)
6 · The paper itself

Abstract

backgroundPatients with obstructive sleep apnea (OSA) are at increased risks of rapid oxygen desaturation during anesthesia, highlighting the need for effective strategies to extend safe apnea time. This study aims to evaluate the efficacy of combining a nasopharyngeal airway (NPA) with transnasal humidified rapid-insufflation ventilator exchange (THRIVE) at 60L/min, compared to THRIVE alone, in prolonging the safe apnea duration and enhancing carbon dioxide elimination in apneic OSA patients.

methodsThis single-center, prospective, double-blind, randomized controlled trial will include 56 adult patients with OSA scheduled for elective surgery under general anesthesia. Participants will be randomized in a 1:1 ratio to receive either NPA + THRIVE or THRIVE alone. Both groups will undergo standard anesthesia induction, including pre-oxygenation via face mask with 100% FiO DISCUSSION: This trial is expected to provide insights into the effectiveness of combining THRIVE with NPA in prolonging safe apnea time and improving carbon dioxide elimination in OSA patients during anesthesia induction. Positive findings could support adoption THRIVE + NPA as a standard practice in managing OSA patients, potentially lowering perioperative risks associated with hypoxia and hypercapnia.

trial registrationThis trial was registered on Clinical Trials.gov(NCT06581588) on Sep 3, 2024.

Indexed as

Oxygen Inhalation TherapySleep Apnea, ObstructiveAdultAnesthesia, GeneralCarbon DioxideDouble-Blind MethodFemaleHumansInsufflationMaleMiddle AgedProspective StudiesRandomized Controlled Trials as TopicCarbon DioxideApneic oxygenationNasopharyngeal airwayObstructive sleep apneaRandomized controlled trialTHRIVE

Identifiers

PMID40217470
PMCPMC11987248

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.