Evidence map›Paper›PMID 40217408›Full record

ArticleActa epileptologica2024

Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis.

Chenxi Qiu, Chenxi Zhong, Ying Liu, Liju Wang, Yingying Tang, Zhiyi Liu, Sijia Guo, Yingqi Jiang, Enzhi Li, Jing Lu and 3 more

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In one paragraph

Article in Acta epileptologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Chenxi Qiu *MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Chenxi Zhong *Department of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.
Ying LiuMOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Liju WangMOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Yingying TangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.
Zhiyi LiuSchool of Public Health, Sichuan University, Chengdu, 610044, China.
Sijia GuoMOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Yingqi JiangDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.
Enzhi LiDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.
Jing LuMOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu , Sichuan, 611731, China.
Bo YanDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China. yanbo@wchscu.edu.cn.
Xiaoting HaoDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China. sherryhao@wchscu.cn.ORCID http://orcid.org/0000-0002-0372-1634
Dong ZhouDepartment of Neurology, West China Hospital, Sichuan University, Chengdu , Sichuan, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a lack of further exploration of the epileptogenic network of specific types of epilepsy, such as unilateral hippocampal sclerosis (HS), and there is an urgent need to find exact evidence to confirm the consistency of its brain network changes.

methodsWe enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) patients to compare the differences in brain activity between 22 healthy controls (HCs) and them. Resting-state electroencephalography (EEG) was also measured. Then, we calculated the power spectral density and phase locking values in and between these electrodes.

resultsThe results showed the increased theta power was related to the high severity of epilepsy in the temporal, parietal, and central regions in mTLE-HS patients, and there were positive correlations between theta power in the contralateral temporal region and seizure frequency. Theta power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications (ASMs), but not with the usage of third-generation ASMs. Meanwhile, the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.

conclusionsTheta power is an important EEG indicator of mTLE-HS, positively correlates with epilepsy severity and seizure frequency, and has network properties that can be observed outside the lesion. Moreover, the usage of third-generation ASMs did not affect the risk of increased theta power. Lastly, the temporoparietal and temporal-central networks are likely to be causative pathways in epilepsy patients with cognitive impairment. This study provides a potential guideline for the treatment of mTLE-HS in clinical practice.

Indexed as

Anti-seizure medicationsElectroencephalographyHippocampal sclerosisMesial temporal lobe epilepsyTheta oscillation

Identifiers

PMID40217408
PMCPMC11960361

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