SynthesisWorld journal of emergency surgery : WJES2025
Alternative treatments to treat perforated peptic ulcer: a systematic review and network meta-analysis of randomized controlled trials.
Synthesis in World journal of emergency surgery : WJES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Outcomes and Predictors of Mortality in Perforated Versus Non-Perforated Peptic Ulcer Disease: A U.S. Nationwide Propensity-Matched Analysis, 2016-2021.Journal of clinical medicine · 2026Article
- Novel use of endoscopic pigtail drainage in recurrent gastric perforation following intentional drug overdose: a case report.Journal of surgical case reports · 2026Article
- Evidence-based, cost-effective management of perforated peptic ulcer disease: An algorithm of the Journal of Trauma and Acute Care Surgery Emergency General Surgery Algorithms Working Group.The journal of trauma and acute care surgery · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPerforated peptic ulcers (PPU) represent a critical surgical emergency. Despite the historical predominance of open surgical repair, laparoscopic and endoscopic approaches have shown promise in reducing morbidity and hospital stay. This study aimed to conduct a network meta-analysis comparing open, laparoscopic, and endoscopic interventions for PPU repair.
methodsA systematic search of Medline (PubMed), Embase, Cochrane Library, Google Scholar, and the National Institute for Health and Clinical Excellence (NICE) databases identified randomized controlled trials (RCTs) comparing these approaches. The primary outcomes were 30-day mortality and morbidity.
resultsEight RCTs including 657 patients were analyzed. Endoscopic interventions were associated with fewer respiratory complications and shorter hospital stays, while the laparoscopic approach demonstrated fewer surgical site infections and less postoperative pain compared to open repair. Other outcomes demonstrated non-significant differences across interventions.
conclusionsPrompt resuscitation and surgical repair, either laparoscopic or open, remains the gold standard for PPU. Endoscopic techniques are viable alternatives for small perforations and in selected cases where general anesthesia is contraindicated.
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Registered trials
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