Evidence map›Paper›PMID 40217243›Full record

ArticleBMC oral health2025

The association between traumatic temporomandibular joint bony ankylosis and depressive disorder in growing rats.

Tiange Deng, Yang Xue, Yiming Wang, Xiang Guo, Zhen Ma, Hongzhi Zhou, Zaiyong Yang, Zhengwu Peng, Xiangxiang Hu, Ning Li and 2 more

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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Tiange Deng *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yang Xue *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Yiming Wang *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Xiang GuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Zhen MaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Hongzhi ZhouState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Zaiyong YangOral Medicine Teaching and Research Office of the War Rescue Medical Department of the, Noncommissioned Officer Schoolaq, Army Medical University, Shijiazhuang, 050081, China.
Zhengwu PengDepartment of Psychiatry, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032, China.
Xiangxiang HuDivision of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, 27514, USA.
Ning LiSchool of Stomatology, Jinzhou Medical University, Jinzhou, 121001, China.
Kaijin HuDepartment of Stomatology, School of Stomatology, Xi'an Medical University, the Third Affiliated Hospital of Xi'an Medical University, 1 Xinwang Road, Xi'an, 710021, China. hukaijin2015@126.com.
Lei WangDepartment of Female Mental Health, Xi'an Mental Health Center, Xi'an Institute of Mental Health, Shaanxi Mental Health Center, Dong Hangtian Road, Xi'an, 710061, China. wangleixsk@sina.cn.

Funding

the General Project of Social Development Field of Shaanxi Natural Science Foundation No. 2024SF-YBXM-263the National Natural Science Foundation of China No. 81970954the New Technology and New Project of the Third Affiliated Hospital of Air Force Military Medical University No. LX2021-332
6 · The paper itself

Abstract

backgroundThe psychological symptoms of temporomandibular joint (TMJ) ankylosis were similar to that of depressive disorder, but there were no relevant evidences to confirm that the humans or animals with TMJ ankylosis had depressive disorder. The aim of this study was to investigate the association between TMJ ankylosis and depressive disorder in the rat model.

methodsThirty 3-week-old male Sprague-Dawley (SD) rats were used in this study. The damage of TMJ complexes and narrowed joint space were performed in the unilateral TMJ of test group to induce TMJ bony ankylosis (experimental side). The other TMJ of test group underwent a sham operation (sham side). The TMJs of control group did not undergo any operations. At 8 weeks postoperatively, behavioral tests, body weight, passive maximum mouth opening (PMMO), and TMJ morphological features were evaluated, and the hippocampuses were analyzed using western blotting and immunocytochemistry. The data was compared between the test group and control group by independent t-test, between the experimental side and sham side by paired t-test. The correlations between PMMO/area of bony fusion and duration of immobility, sucrose preference, CB1 receptor protein, mean optical density of CB1 receptor protein, and the number of BrdU-positive cell were evaluated using linear regression analysis. The level of significance was 0.05.

resultsIn the test group, the traumatic TMJ complexes with narrowed joint space developed TMJ bony ankylosis, the area of bony mass of experimental side (21.26 mm

conclusionsThe present study verified that depressive disorder was found in the rat model of traumatic TMJ bony ankylosis. The severity of TMJ bony ankylosis correlated with the severity of depressive disorder.

Indexed as

AnkylosisDepressive DisorderTemporomandibular Joint DisordersAnimalsBody WeightDisease Models, AnimalHippocampusMaleRange of Motion, ArticularRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Temporomandibular JointReceptor, Cannabinoid, CB1Area of bony fusionBrdU-positive cellCB1 receptor proteinDepressive disorderDuration of immobilityMaximum mouth openingSucrose preferenceTMJ ankylosis

Identifiers

PMID40217243
PMCPMC11992720

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