Evidence map›Paper›PMID 40217174›Full record

ArticleBMC infectious diseases2025

The prognostic role of vegetation size in pediatric infective endocarditis: a retrospective study using decision curve and dose-response analysis.

Yonghan Luo, Xiaotao Yang, Feng Jiao, Yan Guo, Yanchun Wang

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Yonghan LuoSecond Department of Infectious Disease, Kunming Children's Hospital, Yunnan key specialty of pediatric infection (training and education program)/Kunming key specialty of pediatric infection, Kunming, 650000, Yunnan, China.
Xiaotao YangSecond Department of Infectious Disease, Kunming Children's Hospital, Yunnan key specialty of pediatric infection (training and education program)/Kunming key specialty of pediatric infection, Kunming, 650000, Yunnan, China.
Feng JiaoSecond Department of Infectious Disease, Kunming Children's Hospital, Yunnan key specialty of pediatric infection (training and education program)/Kunming key specialty of pediatric infection, Kunming, 650000, Yunnan, China.
Yan GuoFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Yanchun WangSecond Department of Infectious Disease, Kunming Children's Hospital, Yunnan key specialty of pediatric infection (training and education program)/Kunming key specialty of pediatric infection, Kunming, 650000, Yunnan, China. wangyanchun0204@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the predictive value of vegetation size on the prognosis of pediatric infective endocarditis (IE).

methodsA total of 27 children diagnosed with IE who were admitted to Kunming Children's Hospital from January 2014 to June 2024 were included. The good prognosis group comprised 10 cases, while the bad prognosis group comprised 17 cases. The receiver operating characteristic (ROC) curve, restricted cubic spline model, and decision curve analysis were utilized to assess the predictive value of vegetation size on the prognosis of pediatric IE.

resultsThere were statistically significant differences in vegetation size, hemoglobin, platelet count, and prothrombin time between the two groups (P < 0.05). The ROC curve demonstrated that vegetation size had a high predictive accuracy for the prognosis of pediatric IE (AUC = 0.841, 95% CI: 0.775-0.924). Decision curve analysis indicated that vegetation size held substantial clinical value for predicting the prognosis of pediatric IE. The restricted cubic spline analysis revealed a linear dose-response relationship between vegetation size and prognosis of pediatric IE (nonlinear test, P = 0.084).

conclusionSignificant differences were observed in vegetation size, hemoglobin, platelet count, and prothrombin time between different prognosis of pediatric IE. Limited evidence indicates that vegetation size is a critical factor in predicting the prognosis of pediatric IE. However, studies with larger sample sizes are needed to confirm the accuracy of these conclusions.

Indexed as

EndocarditisAdolescentChildChild, PreschoolFemaleHemoglobinsHumansInfantMalePlatelet CountPrognosisProthrombin TimeRetrospective StudiesROC CurveHemoglobinsChildrenDecision curve analysisDose-response analysisInfective endocarditisVegetation size

Identifiers

PMID40217174
PMCPMC11992701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.