Evidence map›Paper›PMID 40217170›Full record

ArticleBMC infectious diseases2025

Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome.

Zhongwei Zhang, Xue Hu, Qian Du, Pingzheng Mo, Xiaoping Chen, Mingqi Luo, Qunqun Jiang, Liping Deng, Yong Xiong

Abstract read
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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhongwei Zhang *Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xue Hu *Department of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, China.
Qian DuDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Pingzheng MoDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiaoping ChenDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Mingqi LuoDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qunqun JiangDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. jqq0105@163.com.
Liping DengDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. dengliping@whu.edu.cn.
Yong XiongDepartment of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China. yongxiong64@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUntil recently, severe fever with thrombocytopenia syndrome (SFTS)-related disseminated intravascular coagulation (DIC) had not been elucidated. This study aimed to explore the clinical characteristics and outcomes of DIC in patients with SFTS.

methodsPatients diagnosed with SFTS who were admitted to Zhongnan Hospital of Wuhan University from August 2016 to October 2023 were included. Patients' demographics and clinical data were collected. According to the presence of DIC, they were assigned into the DIC and non-DIC groups. Independent risk factors for prognosis were identified by univariate and multivariate logistic regression analyses.

resultsA total of 246 consecutive patients diagnosed with SFTS were enrolled, including 216 (87.8%) patients in the non-DIC group and 30 (12.2%) patients in the DIC group. ALT, AST, ALP, GGT, LDH, creatinine, cystatin-C, amylase, lipase, CK, CK-MB, troponin I, BNP, PT, PTA, APTT, TT, FDP, D-dimer, CRP, procalcitonin, IL-6, SAA, ESR, ferritin levels, and viral load were significantly higher in patients with DIC. The cumulative survival rate of patients with DIC was significantly lower than that of patients without DIC. Furthermore, it is demonstrated that the presence of DIC was an independent risk factor for in-hospital mortality of patients with SFTS.

conclusionDIC is a potential complication and is associated with high mortality in patients with SFTS. Early recognition and timely management of this serious complication are important for patients with SFTS.

Indexed as

Disseminated Intravascular CoagulationSevere Fever with Thrombocytopenia SyndromeAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPhlebovirusPrognosisRetrospective StudiesRisk FactorsClinical characteristicsDisseminated intravascular coagulationOutcomesPrevalenceSevere fever with thrombocytopenia syndrome

Identifiers

PMID40217170
PMCPMC11992865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.