ArticleBMC anesthesiology2025
Determination of ED
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Safety and Efficacy of Oliceridine Combined with Propofol for Painless Gastroscopy: A Single-Center, Randomized, Parallel Controlled Clinical Trial.Drug design, development and therapy · 2026Trial
- Oliceridine versus Sufentanil for Postoperative Recovery and Opioid-Related Adverse Events in Patients Undergoing Thoracoscopic Lobectomy: A Randomized Double-Blind Controlled Trial.Drug design, development and therapy · 2026Trial
- The EDDrug design, development and therapy · 2026Trial
- Effective Dose of Oliceridine for Inhibiting Hemodynamic Elevation Induced by Tracheal Intubation: An Up-and-Down Sequential Trial.Drug design, development and therapy · 2025Trial
- Determine of 90% Effective Dose of Oliceridine Combined with Etomidate for Inhibiting Laryngeal Mask Airway Insertion Responses in Patients of Different Ages: A Biased-Coin Sequential Allocation Dose-Finding Trial.Drug design, development and therapy · 2025Trial
- Median effective dose and 95% effective dose of oliceridine combined with ciprofol for painless gastroscopy: a dose-finding study based on Dixon's up-and-down method.Frontiers in pharmacology · 2026Article
- Effective Doses of Oliceridine Combined with Propofol for Painless Hysteroscopy: A Prospective Dose-Finding Study.International journal of general medicine · 2025Article
- Determination of the effective dose of oliceridine combined with propofol using the modified Dixon's up-and-down method in painless gastroscopy.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastroscopy is a common medical procedure, but the insertion of the endoscope often causes significant discomfort and anxiety in patients, necessitating effective sedation strategies. Traditional sedatives, such as propofol, are widely used for procedural sedation but can lead to adverse effects, including respiratory depression and cardiovascular instability at higher doses. Oliceridine, a novel opioid analgesic, has emerged as a potential alternative due to its biased agonist properties, which may provide effective analgesia with a more favorable side effect profile. The potential for its combination with propofol warrants further investigation.
methodsThe ED MEASUREMENTS: The primary outcome measure was the occurrence of body movements or coughing responses during gastroscopy.
resultsA total of 49 patients were included in this study, with anesthesia successfully achieved in 45 cases and failed in 4 cases. The calculated ED
conclusionsThe combination of 2 mg·kg
trial registrationThe study was registered in the Chinese Clinical Trial Registry (ChiCTR2400092318) on November 14, 2024.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.