ArticleBMC cardiovascular disorders2025
The nonlinear correlation of neutrophil-lymphocyte ratio on 1-year mortality risk in patients with severe acute heart failure.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Article
- Association between blood urea nitrogen to albumin ratio and 28-day mortality of acute heart failure in intensive care unit: analysis based on MIMIC-IV database.BMC cardiovascular disorders · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis retrospective cohort study was designed to examine the relationship between the neutrophil-lymphocyte ratio (NLR) and the 1-year risk of death in patients with acute heart failure (AHF) in the intensive care unit (ICU).
methodsWe retrospectively analyzed 1,176 patients with AHF from the MIMIC-IV database. Cox regression was used to evaluate the relationship between NLR and 1-year mortality risk after adjusting for covariates. Nonlinear associations and optimal NLR cutoff values were determined using restricted cubic splines. Propensity score matching was used to eliminate imbalances in the baseline confounders. Kaplan-Meier survival analysis further confirmed the correctness of the threshold. The ROC was used to evaluate the diagnostic accuracy of the NLR for long-term outcomes. Subgroup analyses were performed to assess the generality of NLR in specific populations.
resultsThe mortality rate was lowest in the lower tertile NLR group (< 5.43) and highest in the upper tertile group (> 13.53, P for trend < 0.001). NLR showed a nonlinear correlation with mortality (P for Non-linearity = 0.0075), with the risk increasing significantly when NLR exceeded 11.11. The AUC of NLR for predicting 1-year mortality was 0.579 (95%CI 0.542-0.617). The NLR was not significantly different from long-term outcomes in most groups, but the association was stronger in patients with AHF who did not have sepsis.
conclusionElevated NLR, a marker of heightened systemic inflammation, was associated with a higher risk of 1-year mortality in ICU patients with AHF. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.