Evidence map›Paper›PMID 40217070›Full record

ArticleLeukemia2025

All genetic subtypes of B-cell acute lymphoblastic leukemia exhibit increased incidence rates in children with Down syndrome.

Ching-Ju Hsu, Jeremy M Schraw, Tania A Desrosiers, Amanda E Janitz, Russell S Kirby, Eirini Nestoridi, Wendy N Nembhard, Jason L Salemi, Charles Shumate, Jean Paul Tanner and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ching-Ju HsuDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Jeremy M SchrawDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6674-9562
Tania A DesrosiersDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amanda E JanitzDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Russell S KirbyChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.
Eirini NestoridiDivision for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health, Boston, MA, USA.
Wendy N NembhardDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jason L SalemiChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-0077-6023
Charles ShumateBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, USA.
Jean Paul TannerChiles Center, College of Public Health, University of South Florida, Tampa, FL, USA.
Mahsa M YazdyDivision for Surveillance, Research, and Promotion of Perinatal Health, Massachusetts Department of Public Health, Boston, MA, USA.
Michael E ScheurerDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8379-6088
Karen R Rabin *Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. krrabin@texaschildrens.org.ORCID http://orcid.org/0000-0002-4081-8195
Philip J Lupo *Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. Philip.Lupo@bcm.edu.ORCID http://orcid.org/0000-0003-0978-5863

Funding

Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndromeR01CA249867 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LUPO, PHILIP, RABIN, KAREN R · 2020 to 2024
$4.2M
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric CancerR01CA284531 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Chad Daniel Huff, Philip Lupo · 2023 to 2026
$1.9M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP210027NCI NIH HHS R01 CA249867NCI NIH HHS R01 CA284531Rally Foundation (Rally Foundation Inc.) 23CDNO5U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA249867U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA284531
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40217070
PMCPMC12715847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.