Evidence map›Paper›PMID 40216974›Full record

ArticleNPJ digital medicine2025

Fine-grained forecasting of COVID-19 trends at the county level in the United States.

Tzu-Hsi Song, Leonardo Clemente, Xiang Pan, Junbong Jang, Mauricio Santillana, Kwonmoo Lee

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Oral SARS-CoV-2 Infection and Risk for Long Covid.Reviews in medical virology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tzu-Hsi SongVascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Leonardo ClementeDepartment of Physics and Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA.
Xiang PanVascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Junbong JangVascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Mauricio SantillanaDepartment of Physics and Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA. m.santillana@northeastern.edu.
Kwonmoo LeeVascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. kwonmoo.lee@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-6838-7094

Funding

Unraveling subcellular heterogeneity of molecular coordination by machine learningR35GM133725 · NIGMS · WORCESTER POLYTECHNIC INSTITUTE · PI Kwonmoo Lee · 2019 to 2026
$3.9M
Development of an Open-Source and Data-Driven Modeling Platform to Monitor and Forecast Disease ActivityR01GM130668 · NIGMS · NORTHEASTERN UNIVERSITY · PI SANTILLANA, MAURICIO · 2018 to 2022
$1.9M
NIGMS NIH HHS R01 GM130668NIGMS NIH HHS R35 GM133725U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC) 200-2016-91779U.S. Department of Health & Human Services | Centers for Disease Control and Prevention (CDC) CDC-RFAFT-23-0069U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM130668U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM133725
6 · The paper itself

Abstract

The novel coronavirus (COVID-19) pandemic has had a devastating global impact, profoundly affecting daily life, healthcare systems, and public health infrastructure. Despite the availability of treatments and vaccines, hospitalizations and deaths continue. Real-time surveillance of infection trends supports resource allocation and mitigation strategies, but reliable forecasting remains a challenge. While deep learning has advanced time-series forecasting, its effectiveness relies on large datasets, a significant obstacle given the pandemic's evolving nature. Most models use national or state-level data, limiting both dataset size and the granularity of insights. To address this, we propose the Fine-Grained Infection Forecast Network (FIGI-Net), a stacked bidirectional LSTM structure designed to leverage county-level data to produce daily forecasts up to two weeks in advance. FIGI-Net outperforms existing models, accurately predicting sudden changes such as new outbreaks or peaks, a capability many state-of-the-art models lack. This approach could enhance public health responses and outbreak preparedness.

Identifiers

PMID40216974
PMCPMC11992165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.