Evidence map›Paper›PMID 40216939›Full record

ArticleThe EMBO journal2025

Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.

Rosa Pascual, Jinming Cheng, Amelia H De Smet, Bianca D Capaldo, Minhsuang Tsai, Somayeh Kordafshari, François Vaillant, Xiaoyu Song, Göknur Giner, Michael J G Milevskiy and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rosa PascualACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-7316-5696
Jinming ChengACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-3806-4694
Amelia H De SmetACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Bianca D CapaldoACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0002-0018-6920
Minhsuang TsaiACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Somayeh KordafshariACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
François VaillantACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0003-3229-3760
Xiaoyu SongACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0009-0000-2450-2230
Göknur GinerBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Michael J G MilevskiyACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Felicity C JacklingACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Bhupinder PalTranslational Breast Cancer Program, Olivia Newton-John Cancer Research Institute and School for Cancer Medicine La Trobe University, Heidelberg, VIC, 3084, Australia.
Toby DiteDepartment of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Jumana YousefDepartment of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-2364-6299
Laura F DagleyDepartment of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Gordon K SmythBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-9221-2892
Naiyang FuACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Geoffrey J LindemanACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.ORCID http://orcid.org/0000-0001-9386-2416
Yunshun ChenACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Jane E VisvaderACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. visvader@wehi.edu.au.ORCID http://orcid.org/0000-0001-9173-6977

Funding

Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 1176199,1154970,2025645,1078730,1175960,1037230,1102742National Breast Cancer Foundation (NBCF) IIRS-20-022
6 · The paper itself

Abstract

Fibroblasts form a major component of the stroma in normal mammary tissue and breast tumors. Here, we have applied longitudinal single-cell transcriptome profiling of >45,000 fibroblasts in the mouse mammary gland across five different developmental stages and during oncogenesis. In the normal gland, diverse stromal populations were resolved, including lobular-like fibroblasts, committed preadipocytes and adipogenesis-regulatory, as well as cycling fibroblasts in puberty and pregnancy. These specialized cell types appear to emerge from CD34

Indexed as

CarcinogenesisFibroblastsMammary Glands, AnimalMorphogenesisAnimalsAntigens, CD34Breast NeoplasmsCancer-Associated FibroblastsCellular SenescenceFemaleGene Expression ProfilingMiceSingle-Cell AnalysisWnt ProteinsAntigens, CD34Wnt ProteinsCancer-Associated Fibroblasts (CAFs)FibroblastsMammary Gland DevelopmentSenescenceWnt9a

Identifiers

PMID40216939
PMCPMC12130467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.