Evidence map›Paper›PMID 40216851›Full record

ArticleScientific reports2025

Malvidin-3-glucoside induces insulin secretion by activating the PLC/IP

Pilailak Channuwong, Yuanying Yuan, Shaomian Yao, Fernando Vicosa Bauermann, Henrique Cheng, Tanyawan Suantawee, Sirichai Adisakwattana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pilailak ChannuwongCenter of Excellence in Phytochemical and Functional Food for Clinical Nutrition, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Yuanying YuanDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Shaomian YaoDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Fernando Vicosa BauermannDepartment of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, 74078, USA.
Henrique ChengDepartment of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, 74078, USA. henrique.cheng@okstate.edu.
Tanyawan SuantaweeCenter of Excellence in Phytochemical and Functional Food for Clinical Nutrition, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. Tanyawan.S@chula.ac.th.
Sirichai AdisakwattanaCenter of Excellence in Phytochemical and Functional Food for Clinical Nutrition, Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

Funding

The National Research Council of Thailand (NRCT) NRCT5-RGJ63001-014
6 · The paper itself

Abstract

Malvidin-3-glucoside (M3G), an anthocyanin found in blueberries and grapes, shows promise as a natural anti-diabetic agent. However, its effect on insulin secretion and its underlying mechanisms remains unclear. This study investigated the impact of M3G on β-cells (INS-1) through real-time Ca

Indexed as

AnthocyaninsCalciumGlucosidesInositol 1,4,5-TrisphosphateInsulinInsulin-Secreting CellsInsulin SecretionType C PhospholipasesAnimalsCalcium Channels, L-TypeCalcium SignalingCell LineEndoplasmic ReticulumGlucoseInositol 1,4,5-Trisphosphate ReceptorsRatsAnthocyaninsCalciumCalcium Channels, L-TypeGlucoseGlucosidesInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinType C PhospholipasesCalcium signalsInsulin secretionL-type voltage-dependent Ca2+ channelsMalvidin-3-glucosidePancreatic β-cellsPLC/IP3

Identifiers

PMID40216851
PMCPMC11992297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.