Evidence map›Paper›PMID 40216850›Full record

ArticleScientific reports2025

Diffuse pulmonary ossification and its association with cicatricial organising pneumonia in idiopathic and secondary forms.

Yasuhiro Terasaki, Yasuhiko Nishioka, Yusuke Kajimoto, Yuko Toyoda, Akira Hebisawa, Takeshi Johkoh, Ryoko Egashira, Takeshi Hisada, Masamichi Mineshita, Tomohisa Baba and 15 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

25 authors.

Yasuhiro TerasakiDivision of Pathology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8603, Japan. terasaki@nms.ac.jp.
Yasuhiko NishiokaDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770- 8503, Japan.
Yusuke KajimotoDepartment of Analytic Human Pathology, Nippon Medical School, 1-25-1 Nezu, Bunkyo-Ku, Tokyo, 113-0031, Japan.
Yuko ToyodaDepartment of Internal Medicine, Japanese Red Cross Kochi Hospital, 1-4-63-11, Hadnaminami-Machi, Kochi, 780-8562, Japan.
Akira HebisawaDivision of Clinical Pathology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, Tokyo, 204-8585, Japan.
Takeshi JohkohDepartment of Radiology, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan.
Ryoko EgashiraDepartment of Radiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Takeshi HisadaDepartment of Respiratory Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa Machi, Maebashi, 371-8514, Japan.
Masamichi MineshitaDepartment of Respiratory Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, 216-8511, Japan.
Tomohisa BabaDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Centre, 6-16-1 Tomioka-Higashi, Kanazawa-Ku, Yokohama, 236-0051, Japan.
Yuji FujikuraDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359- 8513, Japan.
Motoyasu KatoDepartment of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Kazuya IchikadoDepartment of Respiratory Medicine, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Minami-Ku, Kumamoto, 861-4193, Japan.
Yoshikazu InoueClinical Research Center, NHO Kinki Chuo Chest Medical Center, 1180 Nagasonecho, Kita-Ku, Sakai, 591-8555, Japan.
Shinyu IzumiDepartment of Respiratory Medicine, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-Ku, Tokyo, 162-8655, Japan.
Yoshinori HasegawaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, 2-10-39 Shibata, Kita-Ku, Osaka, 530-0012, Japan.
Tomohiro HandaDepartment of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, 54 Shogoinkawahara-Cho, Sakyo-Ku, Kyoto, 6068507, Japan.
Koko HidakaDepartment of Respiratory Medicine, National Hospital Organization Kokura Medical Center, 10-1 Harugaoka, Kokuraminami-Ku, Kitakyushu, Fukuoka, 802-8533, Japan.
Shu HisataDivision of Pulmonary Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Chisato HonjoDepartment of Respiratory Medicine, University of Fukui Hospital, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193, Japan.
Takumi KishimotoDepartment of Medicine, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Minami-Ku, Okayama, 702-8055, Japan.
Masaki OkamotoDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan.
Mari YamasueDepartment of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu, 879-5593, Japan.
Mika TerasakiDepartment of Analytic Human Pathology, Nippon Medical School, 1-25-1 Nezu, Bunkyo-Ku, Tokyo, 113-0031, Japan.
Takafumi SudaSecond Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuou-Ku, Hamamatsu, 431-3192, Japan.

Funding

a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan 20K08553
6 · The paper itself

Abstract

Diffuse pulmonary ossification (DiPO) is characterised by widespread ectopic bone formation in the lungs. Idiopathic DiPO (I-DiPO) poses significant diagnostic challenges and its ossification mechanism remains unclear. Cicatricial organising pneumonia (CiOP) lesions form fibrous nodules without damaging lung structure. We investigated the histopathological features of I-DiPO, focusing on the surrounding fibrosis, and compared them with those of secondary DiPO (S-DiPO). An analysis was conducted using data from a nationwide DiPO survey in Japan. The dataset included clinical, radiological, and histopathological data of patients with suspected I-DiPO. The specific patterns of ossification and fibrotic findings such as CiOP, organising pneumonia (OP), and subpleural fibrosis were identified. Eighteen and seven patients were classified as having I-DiPO and S-DiPO, respectively. I-DiPO affects younger patients, progresses slowly, commonly occurs in the lower lungs, and has a lower mortality rate. S-DiPO affects older patients, presents with widespread lung lesions, and has a higher mortality rate. CiOP lesions were found in direct continuity with or near ossified lesions in 61.1% and 71.4% of patients with I-DiPO and S-DiPO, respectively. OP, CiOP, and ossified lesions often observed in the same locations in S-DiPO. DiPO has a unique pathogenesis, with an ossification transition occurring via the CiOP lesions. These findings provide valuable insights for future diagnostic approaches and management strategies for this condition.

Indexed as

Cryptogenic Organizing PneumoniaLungLung DiseasesOssification, HeterotopicPneumoniaAdultAgedAged, 80 and overFemaleHumansJapanMaleMiddle AgedCicatricial organising pneumoniaDendritic pulmonary ossificationDiffuse pulmonary ossificationIdiopathic diffuse pulmonary ossificationSecondary diffuse pulmonary ossification

Identifiers

PMID40216850
PMCPMC11992120

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